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PopovychIgor L., Mysula Igor R., Popovych Dariya V., Mysula Yuriy I., Sydliaruk Nataliya I., Yavorska Oksana L., Zukow Walery. Role of trace elements of mineral waters in their effects on neuro-endocrine-immune complex at female rats. Journal of Education, Health and Sport. 2021;11(10):373-384. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.10.035 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.10.035 https://zenodo.org/record/5856442 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 10.10.2021. Revised: 20.10.2021. Accepted: 30.10.2021. ROLE OF TRACE ELEMENTS OF MINERAL WATERS IN THEIR EFFECTS ON NEURO-ENDOCRINE-IMMUNE COMPLEX AT FEMALE RATS Igor L. Popovych1, Igor R. Mysula2, Dariya V. Popovych2, Yuriy I. Mysula2, Nataliya I. Sydliaruk2, Oksana L. Yavorska2, Walery Zukow3* 1OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine 2IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine 3Nicolaus Copernicus University, Torun, Poland *w.zukow@wp.pl Abstract Background. Drinking mineral water is one of the ethnopharmacologic factors. Previously, we identified the role of organic carbon and nitrogen of mineral waters in their effects on certain metabolic and neuro-endocrine-immune parameters. The purpose of this study is to clarify the role of trace elements of same mineral waters in their effects on neuro-endocrine-immune complex parameters. Material and methods. Experiment was performed on 48 healthy female Wistar rats 240-290 g divided into 5 groups. Animals of the first group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. In the second group we administered the water Naftussya from the Truskavets’ layer (Galychyna, Ukraine), in the third group the water Sophiya of the Truskavets’ field. The rats of the fourth group received the native water from the Hertsa (Bucovyna, Ukraine) field, and the last group received its artificial salt analogue. The day after the completion of the drinking course in all rats HRV, endocrine and immunne parameters were registered. Results. The trace elements (fluoride, bromide, iodide, meta-silicic and orthoboric acids) of the chemical composition of loading fluids determine their effect on the neuro-endocrine parameters by 59%, on the immune parameters by 84%. Conclusion. The trace elements (fluoride, bromide, iodide, meta-silicic and orthoboric acids) of mineral waters play an essential role in their effects on the neuro-endocrine-immune parameters of female rats. Keywords: Mineral waters, trace elements, female rats, neuro-endocrine-immune parameters, relationships. |
