Intraventricular microinjections of a stable analogue of prostaglandin endoperoxide cause fever in rabbits
Autor: | H Laburn, C J Harrisberg, D Mitchell |
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Rok vydání: | 1979 |
Předmět: |
Male
Dose-Response Relationship Drug Microinjections Physiology Indomethacin Prostaglandin Rectal temperature Pharmacology Stimulation Chemical Body Temperature Prostaglandin Endoperoxides Synthetic chemistry.chemical_compound chemistry Biochemistry Thromboxanes Animals Female lipids (amino acids peptides and proteins) Arachidonic acid Rabbits Prostaglandin endoperoxide Injections Intraventricular Research Article |
Zdroj: | The Journal of Physiology. 291:29-35 |
ISSN: | 0022-3751 |
DOI: | 10.1113/jphysiol.1979.sp012797 |
Popis: | 1. Derivatives of arachidonic acid other than prostaglandin are pyrogenic, the likely candidates being the prostaglandin endoperoxides and/or the thromboxanes. 2. Intraventricular microinjections in rabbits of a stable analogue of prostaglandin endoperoxide resulted in dose-dependent increases of rectal temperature. The pyrexia was delayed in onset; no significant change in body temperature occurred for at least an hour. 3. The pyrexia was unaltered by simultaneous injection of the potent prostaglandin synthetase inhibitor indomethacin. 4. We suggest that both prostaglandins and prostaglandin endoperoxides may be implicated in fever. |
Databáze: | OpenAIRE |
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