Intraventricular microinjections of a stable analogue of prostaglandin endoperoxide cause fever in rabbits

Autor: H Laburn, C J Harrisberg, D Mitchell
Rok vydání: 1979
Předmět:
Zdroj: The Journal of Physiology. 291:29-35
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1979.sp012797
Popis: 1. Derivatives of arachidonic acid other than prostaglandin are pyrogenic, the likely candidates being the prostaglandin endoperoxides and/or the thromboxanes. 2. Intraventricular microinjections in rabbits of a stable analogue of prostaglandin endoperoxide resulted in dose-dependent increases of rectal temperature. The pyrexia was delayed in onset; no significant change in body temperature occurred for at least an hour. 3. The pyrexia was unaltered by simultaneous injection of the potent prostaglandin synthetase inhibitor indomethacin. 4. We suggest that both prostaglandins and prostaglandin endoperoxides may be implicated in fever.
Databáze: OpenAIRE