Platelet function in disseminated intravascular coagulation: A systematic review

Autor:	Julie Brogaard Larsen, Anne-Mette Hvas, Mathies Appel Laursen
Rok vydání:	2018
Předmět:	Blood Platelets medicine.medical_specialty Platelet Aggregation Platelet Function Tests 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Internal medicine medicine Animals Humans Platelet Platelet activation Disseminated Intravascular Coagulation/blood Blood Coagulation Disseminated intravascular coagulation Human studies business.industry Hematology General Medicine Disseminated Intravascular Coagulation Platelet Activation medicine.disease Thrombosis Pathophysiology Clinical Practice Disease Models Animal Population Surveillance 030220 oncology & carcinogenesis Blood Platelets/metabolism Animal studies business Biomarkers circulatory and respiratory physiology
Zdroj:	Laursen, M A, Larsen, J B & Hvas, A-M 2018, ' Platelet function in disseminated intravascular coagulation : A systematic review ', Platelets, vol. 29, no. 3, pp. 238-248 . https://doi.org/10.1080/09537104.2018.1442567
ISSN:	1369-1635 0953-7104
DOI:	10.1080/09537104.2018.1442567
Popis:	Disseminated intravascular coagulation (DIC) has a well-examined pathophysiology, yet some essential elements remain undetermined. During DIC, platelets play an important role in the development of micro thrombosis, but changes in platelet function parameters and their association with development of DIC have not been established. The present systematic review investigated reported associations between platelet function (activation, aggregation, and adhesion) and DIC. We performed a literature search in Embase and PubMed, following the Preferred Reporting Items for Systematic and Meta-Analyses (PRISMA) guidelines. In total, 22 articles were included; 14 human studies, seven animal studies, and one with both human and animal subjects. Platelet activation markers were generally reported to be higher in both DIC patients and animals with DIC than healthy controls, and higher among patients with DIC than patients without DIC. Six human and six animal studies investigated platelet aggregation, which were overall reported to be lower in DIC than in non-DIC or in healthy controls in both human and animal studies. Platelet aggregation was deemed to be confounded by low platelet counts, which are known to affect platelet aggregation analyses even within the reference interval. In conclusion, platelet activation analyses showed promise in diagnosis of DIC, but semi-automatization and standardization are warranted before these can be implemented in daily clinical practice. Changes in platelet aggregation analyses during DIC remain inconclusive, and further studies including adjustment for low platelet count are needed to clarify the role of platelet aggregation in DIC.
Databáze:	OpenAIRE
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