Modulation of neuroplasticity-related targets following stress-induced acute escape deficit
| Autor: | Johanna Maria Catharina Blom, Cristina Benatti, Silvia Alboni, Nicoletta Brunello, Fabio Tascedda, G. Radighieri |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Gene Expression Prefrontal Cortex Hippocampus Nerve Tissue Proteins Behavioral neuroscience Biology Acute escape deficit Prefrontal cortex Resilience Stress Transcriptional effect Behavioral Neuroscience Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Escape Reaction Neurotrophic factors PAS domain Adaptation Psychological Gene expression Neuroplasticity Basic Helix-Loop-Helix Transcription Factors Animals 030304 developmental biology 0303 health sciences Neuronal Plasticity Arc (protein) Brain-Derived Neurotrophic Factor Brain Rats Cytoskeletal Proteins Models Animal Neuroscience Stress Psychological 030217 neurology & neurosurgery |
| Popis: | Understanding resilience is a major challenge to improve current pharmacological therapies aimed at complementing psychological-based approaches of stress-related disorders. In particular, resilience is a multi-factorial construct where the complex network of molecular events that drive the process still needs to be resolved. Here, we exploit the acute escape deficit model, an animal model based on exposure to acute unavoidable stress followed by an escape test, to define vulnerable and resilient phenotypes in rats. Hippocampus and prefrontal cortex (PFC), two of the brain areas most involved in the stress response, were analysed for gene expression at two different time points (3 and 24 h) after the escape test. Total Brain-Derived Neurotrophic Factor (BDNF) was highly responsive in the PFC at 24-h after the escape test, while expression of BDNF transcript IV increased in the hippocampus of resistant animals 3 h post-test. Expression of memory enhancers like Neuronal PAS Domain Protein 4 (Npas4) and Activity-regulated cytoskeleton-associated protein (Arc) decreased in a time- and region-dependent fashion in both behavioural phenotypes. Also, the memory inhibitor Protein Phosphatase 1 (Ppp1ca) was increased in the hippocampus of resilient rats at 3 h post-test. Given the importance of neurotrophic factors and synaptic plasticity-related genes for the development of appropriate coping strategies, our data contribute to an additional step forward in the comprehension of the psychobiology of stress and resiliency. |
| Databáze: | OpenAIRE |
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