Functionalization of filled radioactive multi-walled carbon nanocapsules by arylation reaction for in vivo delivery of radio-therapy
| Autor: | Khuloud T. Al-Jamal, Gerard Tobias, Jean-Claude Saccavini, Rebecca Klippstein, Julie Tzu-Wen Wang, Elzbieta Pach, Robert Feldman, Belén Ballesteros, Agnieszka Gajewska, Markus Martincic, Tatiana Da Ros |
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| Přispěvatelé: | European Commission, Biotechnology and Biological Sciences Research Council (UK), Ministerio de Economía y Competitividad (España), Generalitat de Catalunya, Gajewska, A., Wang, J. T., Klippstein, R., Martincic, M., Pach, E., Feldman, R., Saccavini, J. -C., Tobias, G., Ballesteros, B., Al-Jamal, K. T., Da Ros, T. |
| Rok vydání: | 2021 |
| Předmět: |
Radioisotope
Nanocapsule Lung Neoplasms Biocompatible Materials 02 engineering and technology Injections Intravenou 01 natural sciences Chloride law.invention Mice Biodistribution law Materials Testing General Materials Science Tissue Distribution Animals Glioma Injections Intravenous Melanoma Molecular Structure Nanocapsules Nanotubes Carbon Particle Size Radioisotopes Samarium Biocompatible Material Nanotubes General Medicine Permeation 021001 nanoscience & nanotechnology 3. Good health 0210 nano-technology Intravenous medicine.drug MRI Biomedical Engineering chemistry.chemical_element Carbon nanotube 010402 general chemistry Diazonium Injections In vivo medicine Animal Radiochemistry General Chemistry Carbon 0104 chemical sciences Lung Neoplasm chemistry Surface modification |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Journal of Materials Chemistry B |
| Popis: | Functionalized multi-walled carbon nanotubes (MWCNTs) containing radioactive salts are proposed as a potential system for radioactivity delivery. MWCNTs are loaded with isotopically enriched 152-samarium chloride (152SmCl3), the ends of the MWCNTs are sealed by high temperature treatment, and the encapsulated 152Sm is neutron activated to radioactive 153Sm. The external walls of the radioactive nanocapsules are functionalized through arylation reaction, to introduce hydrophilic chains and increase the water dispersibility of CNTs. The organ biodistribution profiles of the nanocapsules up to 24 h are assessed in naïve mice and different tumor models in vivo. By quantitative γ-counting, 153SmCl3@MWCNTs-NH2 exhibite high accumulation in organs without leakage of the internal radioactive material to the bloodstream. In the treated mice, highest uptake is detected in the lung followed by the liver and spleen. Presence of tumors in brain or lung does not increase percentage accumulation of 153SmCl3@MWCNTs-NH2 in the respective organs, suggesting the absence of the enhanced permeation and retention effect. This study presents a chemical functionalization protocol that is rapid (∼one hour) and can be applied to filled radioactive multi-walled carbon nanocapsules to improve their water dispersibility for systemic administration for their use in targeted radiotherapy. We thank Thomas Swan & Co. Ltd for supplying the Eli-carb® MWCNTs. This work was supported by European Union's Seventh Framework Programme FP7, Project “RADDEL” [grant number 290023], Worldwide Cancer Research [grant number 12-1054], Biotechnology and Biological Sciences Research Council [grant number BB/J008656/1], European Union HORIZON 2020 MSCA RISE 2016, Project Carbo-Immap [grant number 734381], “Severo Ochoa” Programme for Centres of Excellence in R&D [grant numbers SEV-2015-0496, SEV-2017-0706], and Generalitat de Catalunya 2017 [grant number SGR 327]. With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000917-S). |
| Databáze: | OpenAIRE |
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