FFAR from the Gut Microbiome Crowd: SCFA Receptors in T1D Pathology
| Autor: | Medha Priyadarshini, Sophie Gough, Barton Wicksteed, Brian T. Layden, Kai Xu, Kristen Lednovich |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty insulin secretion endocrine system diseases type 1 diabetes Endocrinology Diabetes and Metabolism short-chain fatty acids Incretin gut microbiome 030209 endocrinology & metabolism Context (language use) Disease Type 2 diabetes Review Biology Biochemistry digestive system Microbiology 03 medical and health sciences 0302 clinical medicine free fatty acid receptor (FFA) 2 medicine Receptor Molecular Biology digestive oral and skin physiology nutritional and metabolic diseases FFA3 medicine.disease Gut microbiome incretin QR1-502 Review article 030104 developmental biology Metabolic syndrome |
| Zdroj: | Metabolites, Vol 11, Iss 302, p 302 (2021) Metabolites |
| ISSN: | 2218-1989 |
| Popis: | The gut microbiome has emerged as a novel determinant of type 1 diabetes (T1D), but the underlying mechanisms are unknown. In this context, major gut microbial metabolites, short-chain fatty acids (SCFAs), are considered to be an important link between the host and gut microbiome. We, along with other laboratories, have explored how SCFAs and their cognate receptors affect various metabolic conditions, including obesity, type 2 diabetes, and metabolic syndrome. Though gut microbiome and SCFA-level changes have been reported in T1D and in mouse models of the disease, the role of SCFA receptors in T1D remains under explored. In this review article, we will highlight the existing and possible roles of these receptors in T1D pathology. We conclude with a discussion of SCFA receptors as therapeutic targets for T1D, exploring an exciting new potential for novel treatments of glucometabolic disorders. |
| Databáze: | OpenAIRE |
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