Inhibition by Theanine of Binding of [3H]AMPA, [3H]Kainate, and [3H]MDL 105,519 to Glutamate Receptors
| Autor: | Takami Kakuda, Ayumu Nozawa, Hitoshi Niino, Akio Sugimoto |
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| Rok vydání: | 2002 |
| Předmět: |
Indoles
Kainate receptor AMPA receptor Pharmacology Biology Tritium Applied Microbiology and Biotechnology Biochemistry Neuroprotection Analytical Chemistry chemistry.chemical_compound Glutamates Animals Receptor alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Molecular Biology Neurons Kainic Acid Organic Chemistry Glutamate receptor General Medicine Theanine Rats Receptors Glutamate chemistry Glycine NMDA receptor Excitatory Amino Acid Antagonists Protein Binding Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 66:2683-2686 |
| ISSN: | 1347-6947 0916-8451 |
| DOI: | 10.1271/bbb.66.2683 |
| Popis: | In an investigation of the mechanisms of the neuroprotective effects of theanine (gamma-glutamylethylamide) in brain ischemia, inhibition by theanine of the binding of [3H](RS)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, and [3H](E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1-H-indole-2-carboxylic acid (MDL 105,519) to glutamate receptors was studied in terms of its possible inhibiting effects on the three receptor subtypes (AMPA, kainate, and NMDA glycine), with rat cortical neurons. Theanine bound the three receptors, but its IC50 of theanine was 80- to 30,000-fold less than that of L-glutamic acid. |
| Databáze: | OpenAIRE |
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