Influenza A(H1N1)pdm09 but not A(H3N2) virus infection induces durable sero-protection: results from the Ha Nam cohort
| Autor: | Juliet E. Bryant, Tran Nhu Duong, Hoang Vu Mai Phuong, Pham Quang Thai, Le Nguyen Minh Hoa, Peter Horby, Annette Fox, H. Rogier van Doorn, Heiman F. L. Wertheim, Dang Duc Anh, Le Thi Thanh, Louise A. Carolan, Arseniy Khvorov, Nguyen Le Khanh Hang, Sheena G. Sullivan, Le Quynh Mai |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Veterinary medicine
medicine.disease_cause Antibodies Viral Virus Influenza A Virus H1N1 Subtype All institutes and research themes of the Radboud University Medical Center Influenza Human Influenza A virus Immunology and Allergy Medicine Humans Seroconversion biology business.industry Transmission (medicine) Influenza A Virus H3N2 Subtype Hemagglutination Inhibition Tests Titer Infectious Diseases lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] Influenza Vaccines Cohort biology.protein Antibody business Cohort study |
| Zdroj: | The Journal of Infectious Diseases, 226, 59-69 The Journal of Infectious Diseases, 226, 1, pp. 59-69 |
| ISSN: | 0022-1899 |
| DOI: | 10.1093/infdis/jiaa293 |
| Popis: | Background The extent to which influenza recurrence depends upon waning immunity from prior infection is undefined. We used antibody titers of Ha-Nam cohort participants to estimate protection curves and decay trajectories. Methods Households (270) participated in influenza-like–illness (ILI) surveillance and provided blood at intervals spanning laboratory–confirmed virus transmission. Sera were tested in hemagglutination inhibition assay. Infection was defined as influenza virus-positive ILI and/or seroconversion. Median protective titers were estimated using scaled-logistic regression to model pretransmission titer against infection status in that season, limiting analysis to households with infection(s). Titers were modelled against month since infection using mixed-effects linear regression to estimate decay and when titers fell below protection thresholds. Results From December 2008–2012, 295 and 314 participants were infected with H1N1pdm09-like and A/Perth/16/09-like (H3N2Pe09) viruses, respectively. The proportion protected rose more steeply with titer for H1N1pdm09 than for H3N2Pe09, and estimated 50% protection titers were 19.6 and 37.3, respectively. Postinfection titers started higher against H3N2Pe09 but decayed more steeply than against H1N1pdm09. Seroprotection was estimated to be sustained against H1N1pdm09 but to wane by 8-months for H3N2Pe09. Conclusions Estimates indicate that infection induces durable seroprotection against H1N1pdm09 but not H3N2Pe09, which could in part account for the younger age of A(H1N1) versus A(H3N2) cases. |
| Databáze: | OpenAIRE |
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