Electroacupuncture alleviates diabetic neuropathic pain in rats by suppressing P2X3 receptor expression in dorsal root ganglia
| Autor: | Xueyu Fei, Jianqiao Fang, Siying Qu, Zhao-xia Tai, Hanzhi Wang, Qunqi Hu, Yongliang Jiang, Luhang Chen, Xiaofen He |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Agonist Electroacupuncture medicine.drug_class medicine.medical_treatment Analgesic Pharmacology Rats Sprague-Dawley Cellular and Molecular Neuroscience Diabetic Neuropathies Dorsal root ganglion Ganglia Spinal Animals Medicine Molecular Biology Streptozotocin business.industry Purinergic receptor P2X3 receptor Cell Biology Rats Nociception medicine.anatomical_structure Hyperalgesia DRG Neuropathic pain Diabetic neuropathic pain Original Article medicine.symptom business Receptors Purinergic P2X3 |
| Zdroj: | Purinergic Signalling |
| ISSN: | 1573-9546 1573-9538 |
| Popis: | Diabetic neuropathic pain (DNP) is a troublesome diabetes complication all over the world. P2X3 receptor (P2X3R), a purinergic receptor from dorsal root ganglion (DRG), has important roles in neuropathic pain pathology and nociceptive sensations. Here, we investigated the involvement of DRG P2X3R and the effect of 2 Hz electroacupuncture (EA) on DNP. We monitored the rats’ body weight, fasting blood glucose level, paw withdrawal thresholds, and paw withdrawal latency, and evaluated P2X3R expression in DRG. We found that P2X3R expression is upregulated on DNP, while 2 Hz EA is analgesic against DNP and suppresses P2X3R expression in DRG. To evaluate P2X3R involvement in pain modulation, we then treated the animals with A317491, a P2X3R specific antagonist, or α β-me ATP, a P2X3R agonist. We found that A317491 alleviates hyperalgesia, while α β-me ATP blocks EA’s analgesic effects. Our findings indicated that 2 Hz EA alleviates DNP, possibly by suppressing P2X3R upregulation in DRG. |
| Databáze: | OpenAIRE |
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