Neuronal Firing Rate Homeostasis Is Inhibited by Sleep and Promoted by Wake
| Autor: | Keith B. Hengen, James N. McGregor, Gina G. Turrigiano, Stephen D. Van Hooser, Alejandro Torrado Pacheco |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Period (gene) Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Homeostatic plasticity Neural Pathways Neuroplasticity medicine Animals Homeostasis Rats Long-Evans Wakefulness Memory Consolidation Visual Cortex Neurons Neuronal Plasticity Biochemistry Genetics and Molecular Biology(all) musculoskeletal neural and ocular physiology Sleep in non-human animals Rats 030104 developmental biology Visual cortex medicine.anatomical_structure nervous system Memory consolidation Sleep Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cell. 165:180-191 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2016.01.046 |
| Popis: | Homeostatic mechanisms stabilize neural circuit function by keeping firing rates within a set-point range, but whether this process is gated by brain state is unknown. Here, we monitored firing rate homeostasis in individual visual cortical neurons in freely behaving rats as they cycled between sleep and wake states. When neuronal firing rates were perturbed by visual deprivation, they gradually returned to a precise, cell-autonomous set point during periods of active wake, with lengthening of the wake period enhancing firing rate rebound. Unexpectedly, this resetting of neuronal firing was suppressed during sleep. This raises the possibility that memory consolidation or other sleep-dependent processes are vulnerable to interference from homeostatic plasticity mechanisms. PAPERCLIP. |
| Databáze: | OpenAIRE |
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