Acoustic startle and prepulse inhibition in 40 inbred strains of mice
| Autor: | James F. Willott, Leona H. Gagnon, Kenneth R. Johnson, Jennifer O'Steen, Lisa Tanner, Molly A. Bogue |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Reflex Startle medicine.medical_specialty Startle response genetic structures Mice Inbred Strains Biology Mice Behavioral Neuroscience Inbred strain Reference Values Internal medicine Moro reflex medicine Animal Strain Differences Animals Acoustic reflex Prepulse inhibition medicine.diagnostic_test Strain (biology) Startle reaction Phenotype Endocrinology Acoustic Stimulation Female Neuroscience |
| Zdroj: | Behavioral Neuroscience. 117:716-727 |
| ISSN: | 1939-0084 0735-7044 |
| DOI: | 10.1037/0735-7044.117.4.716 |
| Popis: | A high-throughput phenotype screening protocol was used to measure the acoustic startle response (ASR) and prepulse inhibition (PPI) in mice. ASRs were evoked by noise bursts; prepulses for PPI were 70 dB sound pressure level tones of 4, 12, and 20 kHz. Forty inbred strains of mice were tested (in most cases using 10 males and 10 females of each strain). The data on both the ASR and PPI had high internal and test-retest reliability and showed large differences among inbred strains, indicative of strong genetic influences. Previously obtained measures of hearing sensitivity in the same inbred strains were not significantly correlated with ASR or PPI measures. |
| Databáze: | OpenAIRE |
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