Association of maternal diabetes with neurodevelopmental disorders: autism spectrum disorders, attention-deficit/hyperactivity disorder and intellectual disability
| Autor: | Sixian Zhao, Christina Dalman, Renee M. Gardner, Shuyun Chen, Håkan Karlsson |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty endocrine system diseases Autism Spectrum Disorder type 2 diabetes mellitus Epidemiology Offspring Population Cohort Studies 03 medical and health sciences 0302 clinical medicine Pregnancy attention-deficit hyperactivity disorder mental disorders Intellectual disability medicine Humans Attention deficit hyperactivity disorder AcademicSubjects/MED00860 030212 general & internal medicine education Sweden education.field_of_study business.industry Type 2 Diabetes Mellitus General Medicine Autism spectrum disorders medicine.disease gestational diabetes mellitus Gestational diabetes Diabetes Gestational Diabetes Mellitus Type 2 Attention Deficit Disorder with Hyperactivity Neurodevelopmental Disorders intellectual disability Autism spectrum disorder Autism Female ADHD and ASD business type 1 diabetes mellitus 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Epidemiology |
| ISSN: | 1464-3685 0300-5771 |
| Popis: | Background Maternal diabetes has been associated with a risk of neurodevelopmental disorders (NDDs) in offspring, though the common co-occurrence of autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder (ADHD) and intellectual disability (ID) is rarely considered, nor is the potential for confounding by shared familial factors (e.g. genetics). Methods This population-based cohort study used data from Psychiatry Sweden, a linkage of Swedish national registers, to follow 2 369 680 individuals born from 1987 to 2010. We used population-averaged logit models to examine the association between exposure to maternal type 1 diabetes mellitus (T1DM), pre-gestational type 2 diabetes mellitus (T2DM) or gestational diabetes mellitus (GDM), and odds of NDDs in offspring. Subgroup analysis was then performed to investigate the timings of GDM diagnosis during pregnancy and its effect on the odds of NDDs in offspring. We compared these results to models considering paternal lifetime T1DM and T2DM as exposures. Results Overall, 45 678 individuals (1.93%) were diagnosed with ASD, 20 823 (0.88%) with ID and 102 018 (4.31%) with ADHD. All types of maternal diabetes were associated with odds of NDDs, with T2DM most strongly associated with any diagnosis of ASD (odds ratioadjusted 1.37, 95% confidence interval 1.03–1.84), ID (2.09, 1.53–2.87) and ADHD (1.43, 1.16–1.77). Considering common co-morbid groups, the associations were strongest between maternal diabetes and diagnostic combinations that included ID. Paternal T1DM and T2DM diagnoses were also associated with offspring NDDs, but these associations were weaker than those with maternal diabetes. Diagnosis of GDM between 27 and 30 weeks of gestation was generally associated with the greatest risk of NDDs in offspring, with the strongest associations for outcomes that included ID. Conclusion The association of maternal diabetes with NDDs in offspring varies depending on the co-morbid presentation of the NDDs, with the greatest odds associated with outcomes that included ID. Results of paternal-comparison studies suggest that the above associations are likely to be partly confounded by shared familial factors, such as genetic liability. |
| Databáze: | OpenAIRE |
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