The Potential Impact of High-Risk Human Papillomavirus–Negative Cervical Intraepithelial Neoplasia 2+ on Primary Human Papillomavirus Screening
| Autor: | Rita Passerini, Anna Daniela Iacobone, Ida Pino, Maria Elena Guerrieri, Dorella Franchi, Ailyn Mariela Vidal Urbinati, Fabio Bottari, Eleonora Petra Preti, Noemi Spolti, Raffaela C. Di Pace, Mariacristina Ghioni |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Genotype Uterine Cervical Neoplasms Alphapapillomavirus Cervical intraepithelial neoplasia Linear array 03 medical and health sciences 0302 clinical medicine Cervical carcinoma medicine Humans Papillomaviridae Retrospective Studies Gynecology Potential impact business.industry Papillomavirus Infections Human papillomavirus screening virus diseases Human Papillomavirus Negative General Medicine Uterine Cervical Dysplasia medicine.disease female genital diseases and pregnancy complications 030104 developmental biology Child Preschool 030220 oncology & carcinogenesis Linear Array HPV Genotyping Test Female business |
| Zdroj: | American Journal of Clinical Pathology. 157:130-135 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1093/ajcp/aqab103 |
| Popis: | Objectives To investigate the prevalence of high-risk human papillomavirus (HPV)–negative cervical intraepithelial neoplasia (CIN) and invasive cervical carcinoma (ICC) and to analyze the distribution of other genotypes in this subset. Methods In total, 431 women who underwent excisional surgical treatment for CIN or ICC at the European Institute of Oncology, Milan, Italy, from January 2016 to December 2017 were retrospectively analyzed. The Linear Array HPV genotyping test (Roche Diagnostics) was performed on a postaliquot from high-risk-HPV–negative liquid-based cervical specimens, when available. Patient characteristics and the prevalence of high-risk-HPV–negative CIN grade 2 or worse (CIN2+) were tabulated. We used t tests to compare age between high-risk-HPV–positive and high-risk-HPV–negative patients. Results Overall, 8.9% of CIN2+ and 7.5% of ICC cases were high-risk HPV negative. There was no age difference between high-risk-HPV–negative CIN2+ women (mean [SD], 41.3 [8.7] years) and high-risk-HPV–positive women (mean [SD], 39.5 [9.0] years) (P = .28). The Linear Array result was available in 22 cases. Most high-risk-HPV–negative patients were positive for a single other genotype infection (32.6%). HPV 73 was the most prevalent genotype, followed by HPV 53 and HPV 84. HPV 26 was detected in 1 case of ICC. Conclusions Our results showed a not-negligible proportion of high-risk-HPV–negative CIN2+, suggesting that cotesting would not miss these cases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|