Synthesis of compounds related to the anti-migraine drug eletriptan hydrobromide
| Autor: | Korupolu Raghu Babu, Paul S Douglas, M N V D Hari Kiran, Badarinadh Gupta, N. A. Vekariya, Aminul Islam, Suri Babu Madasu |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Drug
eletriptan media_common.quotation_subject DEPT Pharmacology High-performance liquid chromatography Full Research Paper related substances lcsh:QD241-441 lcsh:Organic chemistry origin Eletriptan Hydrobromide medicine characterization Eletriptan lcsh:Science media_common Active ingredient Chemistry Organic Chemistry Carbon-13 NMR Proton NMR lcsh:Q control medicine.drug Nuclear chemistry |
| Zdroj: | Beilstein Journal of Organic Chemistry Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 1400-1405 (2012) |
| ISSN: | 1860-5397 |
| DOI: | 10.3762/bjoc.8.162 |
| Popis: | Eletriptan hydrobromide (1) is a selective serotonin (5-HT1) agonist, used for the acute treatment of the headache phase of migraine attacks. During the manufacture of eletriptan hydrobromide the formation of various impurities were observed and identified by LC–MS. To control the formation of these impurities during the preparation of active pharmaceutical ingredients, the structure of the impurities must be known. Major impurities of the eletriptan hydrobromide synthesis were prepared and characterized by using various spectroscopic techniques, i.e., mass spectroscopy, FTIR , 1H NMR, 13C NMR/DEPT, and further confirmed by co-injection in HPLC. The present study will be of great help in the synthesis of highly pure eletriptan hydrobromide related compounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|