Lymphocyte surface modulation and cyclic nucleotides I. Topographic correlation of cyclic adenosine 3':5'-monophosphate and immunoglobulin immunofluorescence during lymphocyte capping
| Autor: | William J. Yount, A L Steiner, H S Earp, MJ Logue, Peter D. Utsinger |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Lymphocyte
Immunology Fluorescent Antibody Technique Receptors Antigen B-Cell chemistry.chemical_element Calcium Immunofluorescence Cell membrane Cyclic nucleotide chemistry.chemical_compound Cyclic AMP medicine Immunology and Allergy Cap formation Nucleotide Lymphocytes Calcimycin chemistry.chemical_classification medicine.diagnostic_test Chemistry Cell Membrane Articles Adenosine Molecular biology Cell biology medicine.anatomical_structure medicine.drug |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | The cross-linking of human peripheral lymphocyte surface Ig results in an early association of cyclic adenosine 3':5'-monophosphate (cAMP) and the cell surface Ig patches. Examination of the subsequent stages of cap formation reveals the continued relationship of cAMP and the clustered surface Ig. In addition, the generalized influx of calcium produced by the ionophore A-23187 disrupts human lymphocyte caps. During the process of cap dissolution cAMP is still associated with surface Ig. Therefore, it is hypothesized that the localized concentration of cyclic nucleotide and calcium ion regulates the movement of cell surface constituents by coordinating the function of the cell's contractile and structural elements. |
| Databáze: | OpenAIRE |
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