Full genome analysis of bovine papillomavirus type 1 derived from a calf with severe cutaneous multiple papillomatosis
| Autor: | Takeshi Haga, Kensuke Kiriki, Nanako Yamashita-Kawanishi, Kazuyuki Uchida, Yoshitaka Goto, Masano Tsuzuki, Mizuho Uematsu, James K. Chambers, Hidekatsu Shimakura, Dung T. Le, Shinichi Hatama, Masahiro Yasuda, Wei Zhu, Jianbao Dong |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Skin Neoplasms 040301 veterinary sciences viruses Cattle Diseases Papillomatosis Genome Viral severe papillomatosis Genome Regulatory region 0403 veterinary science 03 medical and health sciences Antigen Virology full genome sequencing medicine Upper gastrointestinal Animals Bovine papillomavirus Bovine papillomavirus 1 Whole genome sequencing calf General Veterinary biology Papilloma business.industry 04 agricultural and veterinary sciences biochemical phenomena metabolism and nutrition biology.organism_classification medicine.disease Note 030104 developmental biology Cattle medicine.symptom business bovine papillomavirus type 1 |
| Zdroj: | SC10201903130003 NARO成果DBa-pub The Journal of Veterinary Medical Science |
| ISSN: | 0916-7250 |
| Popis: | Severe papillomatosis occasionally causes astasia leading to euthanizing cattle. There are currently a limited number of reports on virologic approach in severe bovine papillomatosis. Here we report a full genome characterization of bovine papillomavirus type 1 (BPV-1) from the case of severe papillomatosis. A calf developed numerous papillomas on the skin and some nodules in the upper gastrointestinal tract at seven months old. The skin lesion was diagnosed as the epithelial papilloma with BPV antigen expression, while the gastrointestinal lesions were diagnosed as the fibropapilloma without BPV antigen. Full genome analysis revealed that BPV-1s detected in all the lesions were exactly the same. Compared with the reference BPV-1 sequence, there was a single nucleotide insertion in the upstream regulatory region. |
| Databáze: | OpenAIRE |
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