The Science and Practice of Bone Health in Oncology: Managing Bone Loss and Metastasis in Patients With Solid Tumors
| Autor: | Allan Lipton, Matthew R. Smith, Robert J. Amato, Behrooz Hakimian, Robert G. Uzzo, G. David Roodman, Georgiana K. Ellis |
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| Rok vydání: | 2009 |
| Předmět: |
Male
musculoskeletal diseases Oncology medicine.medical_specialty Osteoporosis Antineoplastic Agents Bone Neoplasms Breast Neoplasms Article Bone resorption Bone remodeling Osteoclast Neoplasms Internal medicine medicine Humans Bone pain Bone Density Conservation Agents business.industry Prostatic Neoplasms Bone metastasis medicine.disease Denosumab medicine.anatomical_structure Female medicine.symptom Multiple Myeloma business Biomarkers medicine.drug |
| Zdroj: | Journal of the National Comprehensive Cancer Network. 7:S-1 |
| ISSN: | 1540-1413 1540-1405 |
| DOI: | 10.6004/jnccn.2009.0080 |
| Popis: | Cancer and its treatment can compromise bone health, leading to fracture, pain, loss of mobility, and hypercalcemia of malignancy. Bone metastasis occurs frequently in advanced prostate and breast cancers, and bony manifestations are commonplace in multiple myeloma. Osteoporosis and osteopenia may be consequences of androgen-deprivation therapy for prostate cancer, aromatase inhibition for breast cancer, or chemotherapy-induced ovarian failure. Osteoporotic bone loss and bone metastasis ultimately share a pathophysiologic pathway that stimulates bone resorption by increasing the formation and activity of osteoclasts. Important mediators of pathologic bone metabolism include substances produced by osteoblasts, such as RANKL, the receptor activator of nuclear factor kappa B ligand, which spurs osteoclast differentiation from myeloid cells. Available therapies are targeted to various steps in cascade of bone metastasis. |
| Databáze: | OpenAIRE |
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