Semi-synthesis of a protease-activatable collagen targeting probe
| Autor: | M Monica Breurken, E. W. Meijer, Maarten Merkx, Edith H. M. Lempens |
|---|---|
| Přispěvatelé: | Protein Engineering, Macromolecular and Organic Chemistry, Macro-Organic Chemistry |
| Rok vydání: | 2011 |
| Předmět: |
Models
Molecular medicine.medical_treatment Plasma protein binding Cleavage (embryo) Protein Structure Secondary Catalysis Protein structure Materials Chemistry medicine Animals Binding site Protease Chemistry Binding protein Metals and Alloys General Chemistry Peptide Fragments Surfaces Coatings and Films Electronic Optical and Magnetic Materials Biochemistry Drug Design Collagen metabolism Ceramics and Composites Collagen Linker Peptide Hydrolases Protein Binding |
| Zdroj: | Chemical Communications, ChemComm, 47(28), 7998-8000. Royal Society of Chemistry |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/c1cc11964h |
| Popis: | A protease-activatable collagen targeting probe (proCNA35) is synthesized by conjugation of a synthetic collagen fragment to the collagen binding protein CNA35 via a protease-cleavable linker. Cleavage of the linker by MMP1 releases the intramolecular inhibition of the collagen binding site and restores its collagen binding capacity. |
| Databáze: | OpenAIRE |
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