Human Papillomavirus Viral Load and Transmission in Young, Recently Formed Heterosexual Couples
| Autor: | François Coutlée, Pierre-Paul Tellier, Eduardo L. Franco, Ann N. Burchell, Emilie Comète, Allita Rodrigues, Michel D. Wissing, Mariam El-Zein, Karolina Louvanto |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Canada medicine.medical_specialty Adolescent Genotype Concordance Polymerase Chain Reaction Young Adult Major Articles and Brief Reports 03 medical and health sciences 0302 clinical medicine Prevalence medicine Humans Immunology and Allergy Sex organ Longitudinal Studies 030212 general & internal medicine Heterosexuality Papillomaviridae Cervical cancer Obstetrics business.industry Incidence Incidence (epidemiology) Papillomavirus Infections Oncogene Proteins Viral Odds ratio Middle Aged Viral Load medicine.disease Confidence interval 3. Good health Sexual Partners Infectious Diseases 030220 oncology & carcinogenesis DNA Viral Capsid Proteins Female business Viral load Follow-Up Studies Cohort study |
| Zdroj: | J Infect Dis |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | BackgroundWe studied the association between human papillomavirus (HPV) viral load (VL) and HPV concordance.MethodsThe HITCH cohort study included young, heterosexual, recently formed, sexually active couples. Questionnaires and genital samples were collected at 0 and 4 months. Samples were tested for HPV DNA by polymerase chain reaction (PCR; Linear Array). VLs of HPV6/11/16/18/31/42/51 were quantified using type-specific real-time PCR. Correlations between VL and type-specific HPV prevalence and incidence were evaluated using multilevel, mixed-effects linear/logistic regression models.Results We included 492 couples. VLs were higher in penile than vaginal samples. VL at subsequent visits correlated significantly within men (r, 0.373), within women (r, 0.193), and within couples (r range: 0.303–0.328). Men with high VL had more type-specific persistent HPV infections (odds ratio [OR], 4.6 [95% confidence interval {CI}, 2.0–10.5]). High VL in men was associated with prevalent (OR, 5.3 [95% CI, 2.5–11.2]) and incident (OR, 6.7 [95% CI, 1.5–30.7]) type-specific HPV infections in their partner. Women’s VL was associated with type-specific HPV prevalence in their partner at the same (OR, 5.9) and subsequent (OR, 4.7) visit.ConclusionsPersistent HPV infections have limited VL fluctuations. VL between sex partners are correlated and seem predictive of transmission episodes. |
| Databáze: | OpenAIRE |
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