Neuroprotective Effect of Curcumin in an Experimental Rat Model of Subarachnoid Hemorrhage
| Autor: | Chih-Shung Wong, Da-Tong Ju, Cecil O. Borel, Chen-Hwan Cherng, Chang-Po Kuo, Li Li Wen, Chun-Mei Chen, Ching-Tang Wu, Chueng-He Lu |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Curcumin Subarachnoid hemorrhage medicine.medical_treatment Blotting Western Intraperitoneal injection Glutamic Acid Sodium Chloride Neuroprotection chemistry.chemical_compound Cerebral vasospasm Malondialdehyde Internal medicine medicine Animals Vasospasm Intracranial Dimethyl Sulfoxide cardiovascular diseases Rats Wistar Dose-Response Relationship Drug Superoxide Dismutase business.industry Anti-Inflammatory Agents Non-Steroidal Neurotoxicity Glutamate receptor Brain Free Radical Scavengers Subarachnoid Hemorrhage Catalase medicine.disease Rats nervous system diseases Disease Models Animal Oxidative Stress Neuroprotective Agents Anesthesiology and Pain Medicine Endocrinology chemistry Basilar Artery Anesthesia business |
| Zdroj: | Anesthesiology. 115:1229-1238 |
| ISSN: | 0003-3022 |
| DOI: | 10.1097/aln.0b013e31823306f0 |
| Popis: | Background Subarachnoid hemorrhage (SAH) causes a high mortality rate and morbidity. It was suggested that oxidant stress plays an important role in neuronal injury after SAH. Therefore, we assessed the effect of curcumin on reducing cerebral vasospasm and neurologic injury in a SAH model in rat. Methods A double-hemorrhage model was used to induce SAH in rats. Groups of animals were treated with intraperitoneal injection of 20 mg/kg curcumin (curcumin group, n = 24) or dimethyl sulfoxide (vehicle group, n = 33), normal saline (SAH group, n = 34) or normal saline (sham group, n = 22), 3 h after SAH induction and daily for 6 days. Glutamate was measured before SAH induction and once daily for 7 days. Glutamate transporter-1, wall thickness and the perimeter of the basilar artery, neurologic scores, neuronal degeneration, malondialdehyde, superoxide dismutase, and catalase activities were assessed. Results Changes of glutamate levels were lower in the curcumin group versus the SAH and vehicle groups, especially on day 1 (56 folds attenuation vs. vehicle). Correspondingly, glutamate transporter-1 was preserved after SAH in curcumin-treated rats. In the hippocampus and the cortex, malondialdehyde was attenuated (30% and 50%, respectively). Superoxide dismutase (35% and 64%) and catalase (34% and 38%) activities were increased in the curcumin rats compared with the SAH rats. Mortality rate (relative risk: 0.59), wall thickness (30%) and perimeter (31%) of the basilar artery, neuron degeneration scores (39%), and neurologic scores (31%) were improved in curcumin-treated rats. Conclusions Curcumin in multiple doses is effective against glutamate neurotoxicity and oxidative stress and improves the mortality rate in rats with SAH. |
| Databáze: | OpenAIRE |
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