Analgesic, anti-inflammatory and anticancer activities of Combretin A and Combretin B isolated from Combretum fragrans F. HOFFM (Combretaceae) leaves
| Autor: | Aisha Faheem, Amadou Dawe, Marius Mbiantcha, Jabeen Almas, Zafar Sidra |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.drug_class Immunology Combretum Nitric Oxide Anti-inflammatory 03 medical and health sciences Mice 0302 clinical medicine In vivo medicine Animals Humans Pharmacology (medical) MTT assay Viability assay Rats Wistar Cytotoxicity Pharmacology Inflammation Analgesics Combretaceae biology Traditional medicine Chemistry Plant Extracts Tumor Necrosis Factor-alpha Anti-Inflammatory Agents Non-Steroidal biology.organism_classification Antineoplastic Agents Phytogenic Triterpenes Rats Plant Leaves 030104 developmental biology Phytochemical 030220 oncology & carcinogenesis Female Reactive Oxygen Species |
| Zdroj: | Inflammopharmacology. 26(6) |
| ISSN: | 1568-5608 |
| Popis: | Previous pharmacological and phytochemical studies showed that, Combretum fragrans F. HOFFM (Combretaceae) is a Cameroonian medicinal plant possessing numerous therapeutic virtues and rich in various active secondary metabolites. In this study, we investigate in vivo anti-nociceptive and anti-inflammatory activity and, in vitro anticancer, anti-TNFα, ROS and NO-inhibitory activities of Combretum A and Combretin B, two triterpenes cycloartane-type isolated from the leaves of Combretum fragrans. The effect on ROS, TNF-α and NO production, anticancer activity and cytotoxicity assay were done using chemiluminescence technique, ELISA kit, colorimetric method, MCF-7 cells and MTT assay, respectively. Antinociceptive and anti-inflammatory activities were estimated using a model of acetic acid, formalin and carrageenan. Combretin A and Combretin B significantly (p |
| Databáze: | OpenAIRE |
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