Prevalence of Pertussis Antibodies in Maternal Blood, Cord Serum, and Infants From Mothers With and Those Without Tdap Booster Vaccination During Pregnancy in Argentina
| Autor: | Gabriela Manonelles, Silvina E Neyro, Marcelo Galas, E.L. Lopez, Jonathan Zintgraff, Oscar Canle, Estella Zapulla, Claudia Lara, A. Fallo, Susana González, Héctor E Davison, Daniela Flavia Hozbor, Miguel Huespe, Silvina Mazzeo |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Pediatrics Cord Adolescent Whooping Cough Biología Argentina Diphtheria-Tetanus-acellular Pertussis Vaccines Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy 030225 pediatrics Prevalence medicine Humans 030212 general & internal medicine biology placental transfer of antibodies Obstetrics Tetanus business.industry pregnancy vaccines pertussis Infant General Medicine Fetal Blood medicine.disease Antibodies Bacterial Vaccination Infectious Diseases Immunization Cord blood Pediatrics Perinatology and Child Health biology.protein Gestation Female maternal immunization Antibody business Tdap immunization |
| Zdroj: | SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP |
| Popis: | Background Morbidity and mortality rates for pertussis in infants are high because disease often occurs before the onset of routine immunization or in those who do not complete a primary immunization series. Pertussis immunization is recommended during pregnancy to achieve antibody levels sufficient to protect young infants. To our knowledge, no previous reports of maternal pertussis immunization results in Latin America exist in the literature. Methods This study compared pertussis antibody levels in newborns from mothers who received or did not receive a tetanus-diphtheria-acellular pertussis vaccination (TdapV) during pregnancy. Each mother's level of immunoglobulin G antibodies against pertussis toxin (IgG-PT) was measured with a validated, specific enzyme-linked immunosorbent assay (ELISA). Results Paired mother and cord serum samples were compared in 105 mothers with and 99 mothers without a TdapV. At birth, the mothers with and those without a TdapV had serum IgG-PT geometric mean concentrations (GMCs) of 35.1 and 9.8 ELISA units (EU)/mL, respectively (P < .0001); cord blood GMCs were 51.3 and 11.6 EU/mL, respectively (P < .0003); and cord blood IgG-PT levels were Instituto de Biotecnología y Biología Molecular Consejo Nacional de Investigaciones Científicas y Técnicas |
| Databáze: | OpenAIRE |
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