Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers
| Autor: | Michael J. Cook, David A. Russell, Marco M. D. Cominetti, Zoë Rachael Goddard, Mark Searcey, Maria A. O'Connell, Isabelle Chambrier, Andrew M. Beekman, María J. Marín |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
Pharmaceutical Science Photodynamic therapy Peptide 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry chemistry.chemical_compound Drug Discovery PEG ratio medicine Epidermal growth factor receptor Pharmacology chemistry.chemical_classification biology Organic Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Chemistry chemistry Colloidal gold Toxicity Phthalocyanine Cancer research biology.protein Molecular Medicine 0210 nano-technology Phototoxicity |
| Zdroj: | RSC Medicinal Chemistry |
| Popis: | Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity. Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK, with selective phototoxicty observed. |
| Databáze: | OpenAIRE |
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