Meta-review on Perforation Model of Subarachnoid Hemorrhage in Mice: Filament Material as a Possible Moderator of Mortality

Autor: Serdar Alpdogan, Timo Sander, Rui Zhang, Dilaware Khan, Xuanchen Li, Huakang Zhou, Ke Li, Ann-Christin Nickel, Baolong Zheng, Anastasiya Skryabin, Simon Schieferdecker, Björn B. Hofmann, Daniel Maximilian Donaldson, Jan Frederick Cornelius, Daniel Hänggi, Sajjad Muhammad
Rok vydání: 2022
Předmět:
Zdroj: Translational Stroke Research.
ISSN: 1868-601X
1868-4483
DOI: 10.1007/s12975-022-01106-4
Popis: Robust preclinical models are inevitable for researchers to unravel pathomechanisms of subarachnoidal hemorrhage (SAH). For the mouse perforation model of SAH, the goal of this meta-review was the determination of variances in mortality, SAH severity grade, and vasospasm, and their experimental moderators, as many researchers are facing with incomparable results. We searched on the databases PubMed, Embase, and Web of Science for articles describing in vivo experiments using the SAH perforation mouse model and measuring mortality, SAH grade, and/or vasospasm. After screening, 42 articles (total of 1964 mice) were included into systematic review and meta-analysis. Certain model characteristics were insufficiently reported, e.g., perforation location (not reported in six articles), filament (material (n = 15) and tip texture (n = 25)), mouse age (n = 14), and weight (n = 10). Used injective anesthetics and location of perforation showed large variation. In a random-effects meta-analysis, the overall animal mortality following SAH was 21.3% [95% CI: 17.5%, 25.7%] and increased with longer observational periods. Filament material significantly correlated with animal mortality (p = 0.024) after exclusion of hyperacute studies (time after SAH induction
Databáze: OpenAIRE
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