Improving the anti-inflammatory activity of 5-aminosalicylic acid by combination with cyanidin-3-glucoside: An in vitro study
| Autor: | Leonor M. Almeida, Sónia R. Pereira, Teresa C.P. Dinis |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Aminosalicylic acid medicine.drug_class p38 mitogen-activated protein kinases Medicine (miscellaneous) Pharmacology Synergistic interaction Anti-inflammatory Anti-inflammatory activity 03 medical and health sciences chemistry.chemical_compound Ingredient 0404 agricultural biotechnology medicine TX341-641 Cyanidin-3-glucoside 030109 nutrition & dietetics Nutrition and Dietetics AP-1 activation Nutrition. Foods and food supply Biological activity 5-aminosalicylic acid 04 agricultural and veterinary sciences 040401 food science In vitro chemistry Anthocyanin Phosphorylation Food Science |
| Zdroj: | Journal of Functional Foods, Vol 63, Iss, Pp-(2019) |
| ISSN: | 1756-4646 |
| Popis: | This study investigated the anti-inflammatory action of cyanidin-3-glucoside (Cy3glc), an anthocyanin widely spread in diet, in comparison and in association with 5-aminosalicylic acid (5-ASA), an anti-inflammatory reference drug for ulcerative colitis. The efficacy, action mechanism and interaction between Cy3glc and 5-ASA were assessed in vitro, in an LPS-activated macrophage cell line. Our data showed a higher effectiveness of Cy3glc in counteracting inflammatory mediators as compared to 5-ASA at the same concentration. In addition, the mixture afforded a better protection than Cy3glc and a much better than 5-ASA, showing a synergistic effect in terms of reducing NO and ROS cellular production. Although neither Cy3glc nor the mixture counteracted LPS-induced NF-κB activation, the mixture strongly inhibited AP-1 translocation to the nucleus and prevented p38 MAPK and JNK phosphorylation suggesting that, the co-administration of a biologically active food ingredient and a medicine could be a potential strategy to increase the medicine therapeutic effect. |
| Databáze: | OpenAIRE |
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