Measurement of aromatisation by a urine technique suitable for the evaluation of aromatase inhibitors in vivo
| Autor: | Ben P. Haynes, S Jacobs, Griggs Lj, Mitchell Dowsett, Per Eystein Lønning |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Estrone Urinary system Breast Neoplasms Urine Biochemistry Biological fluid Breast cancer Aromatase In vivo Internal medicine medicine Humans skin and connective tissue diseases Aromatase inhibition biology Chemistry Aromatase Inhibitors Androstenedione Estrogens medicine.disease Aminoglutethimide Endocrinology biology.protein Molecular Medicine Female |
| Zdroj: | Journal of enzyme inhibition. 4(4) |
| ISSN: | 8755-5093 |
| Popis: | By modification of a recently developed method for separation of radio-labelled urinary oestrogens we were able to separate oestrogen metabolites and measure their isotope ratios in urine following injections of [3H]delta 4-androstenedione and [14C]oestrone. This method provides a useful tool for studying in vivo aromatisation of delta 4-androstenedione into oestrone in breast cancer patients before and during treatment with aromatase inhibitors. |
| Databáze: | OpenAIRE |
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