PlanHab Study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics
Autor: | Marion Hoerl, I. Kumprej, Alexander Crispin, Igor B. Mekjavic, Manfred Thiel, Tadej Debevec, R. Zeller, Matthias Feuerecker, Bernd Johannes, Alexander Choukèr, Ola Eiken, Gustav Schelling, Sandra Matzel, Claudia Strewe |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adenosine Reduced Gravity medicine.medical_treatment Science Kinetics normobaric hypoxia bed rest Muskel- und Knochenstoffwechsel Bed rest Article 03 medical and health sciences 0302 clinical medicine adenosine kinetics Internal medicine medicine Humans Hypoxia Normobaric hypoxia Multidisciplinary Low oxygen Weightlessness Chemistry Microcirculation Oxygen tension 030104 developmental biology Endocrinology Medicine 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Adenosine plays a role in the energy supply of cells and provokes differential, hormone-like functions in circulating cells and various tissues. Its release is importantly regulated by oxygen tension. This renders adenosine and its kinetics interesting to investigate in humans subjected to low oxygen conditions. Especially for space exploration scenarios, hypoxic conditions – together with reduced gravity - represent two foreseen living conditions when planning manned long-duration space missions or planetary habitats. The PlanHab study investigated microgravity through inactivity in bed rest and normobaric hypoxia to examine their independent or combined effect on adenosine and its kinetics. Healthy male subjects (n = 14) completed three 21-day interventions: hypoxic bed rest (HBR); hypoxic ambulatory confinement (HAMB); normoxic bed rest (NBR). The interventions were separated by 4 months. Our hypothesis of a hypoxia-triggered increase in adenosine was confirmed in HAMB but unexpectedly also in NBR. However, the highest adenosine levels were noted following HBR. Furthermore, the percentage of hemolysis was elevated in HBR whereas endothelial integrity markers stayed low in all three interventions. In summary, these data suggest that neocytolysis accounts for these effects while we could reduce evidence for microcirculatory changes. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |