Tangentially migrating neurons assemble a primary cilium that promotes their reorientation to the cortical plate
| Autor: | Camilla Luccardini, Lucie Viou, Theano Irinopoulou, Nathalie Spassky, Jean-Pierre Lechaire, Sergio Espeso Gil, Vera Kiyasova, Thomas Boudier, J.P. Rio, Nicoletta Kessaris, Pierre-Serge Launay, Christine Métin, Chantal Alvarez, Jean-Pierre Baudoin |
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| Přispěvatelé: | Institut du Fer à Moulin, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Microscopie Electronique [IBPS] (IBPS-ME), Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2012 |
| Předmět: |
animal structures
Cyclopamine Ganglionic eminence Neuroscience(all) Neurogenesis Mice Transgenic Basal Ganglia 03 medical and health sciences chemistry.chemical_compound Mice Mice Neurologic Mutants 0302 clinical medicine Microtubule Intraflagellar transport Cell Movement Organelle Animals Hedgehog Proteins Cilia Sonic hedgehog 030304 developmental biology Centrioles Centrosome Cerebral Cortex Neurons 0303 health sciences biology General Neuroscience Cilium Cell Polarity Anatomy Cell biology chemistry biology.protein [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] sense organs 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Neuron Neuron, 2012, 76 (6), pp.1108-1122. ⟨10.1016/j.neuron.2012.10.027⟩ Neuron, Elsevier, 2012, 76 (6), pp.1108-1122. ⟨10.1016/j.neuron.2012.10.027⟩ |
| ISSN: | 1097-4199 0896-6273 |
| Popis: | International audience; In migrating neurons, the centrosome nucleates and anchors a polarized network of microtubules that directs organelle movements. We report here that the mother centriole of neurons migrating tangentially from the medial ganglionic eminence (MGE) assembles a short primary cilium and exposes this cilium to the cell surface by docking to the plasma membrane in the leading process. Primary cilia are built by intraflagellar transport (IFT), which is also required for Sonic hedgehog (Shh) signal transduction in vertebrates. We show that Shh pathway perturbations influenced the leading process morphology and dynamics of MGE cells. Whereas Shh favored the exit of MGE cells away from their tangential migratory paths in the developing cortex, cyclopamine or invalidation of IFT genes maintained MGE cells in the tangential paths. Our findings show that signals transmitted through the primary cilium promote the escape of future GABAergic interneurons from their tangential routes to colonize the cortical plate. |
| Databáze: | OpenAIRE |
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