Eosinophilic Globules in 3 Cases of Glomeruloid Hemangioma of the Head and Neck: A Characteristic Offering More Evidence for Thanatosomes With or Without POEMS
| Autor: | Min W. Lee, Adrian H. Ormsby, Hwajeong Lee, Frederick A. Meier, Chan K. Ma |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Pathology medicine.medical_specialty CD34 Antigens CD34 Dermatology Periodic acid–Schiff stain Organomegaly Pathology and Forensic Medicine Hemangioma Angioma Antigen von Willebrand Factor medicine Humans Hemangioma Capillary Aged POEMS syndrome Inclusion Bodies Neovascularization Pathologic business.industry General Medicine Middle Aged medicine.disease Glomeruloid hemangioma Eosinophils Platelet Endothelial Cell Adhesion Molecule-1 Head and Neck Neoplasms POEMS Syndrome Female medicine.symptom Lysosomes business |
| Zdroj: | The American Journal of Dermatopathology. 30:539-544 |
| ISSN: | 0193-1091 |
| Popis: | Glomeruloid hemangiomas (GHs) are glomeruli-like capillary tufts lined by endothelial cells that contain periodic acid-Schiff (PAS) positive eosinophilic globules (EGs). These hemangiomas are characteristic cutaneous manifestation of POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, and Skin changes). Hemangiomas histologically identical to GHs but not associated with POEMS have recently been designated as papillary hemangiomas. In this report, we present solitary head and neck GHs in 3 patients, 2 without POEMS, with particular attention to the characteristic EGs. We performed immunostains for hemoglobin A, kappa and lambda light chains, factor VIII-related antigen, CD3 1 and CD34, PAS stain after diastase digestion (PASD), and electron microscopic examinations on routinely fixed tissues containing EGs. Eosinophilic globules stained uniformly positive for PASD but only peripherally positive for hemoglobin and light chains on surfaces, with interiors negative for antigens. Factor VIII-related antigen and CD3 1 and CD34 confirmed cells containing EGs to be endothelial. Electron microscopic examination suggested that EGs are enlarged secondary lysosomes (thanatosomes). These features fail to support red blood cells or immunoglobulins as EG constituents. Glomemloid hemangiomas may be vascular proliferations stimulated by endothelial cells' protein phagocytosis but not by phagocytosis of either hemoglobin-containing red blood cells or immunoglobulins. The vascular lesions in POEMS syndrome appear identical to papillary hemangioma in cases without the other syndromic manifestations. |
| Databáze: | OpenAIRE |
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