Urinary properdin excretion is associated with intrarenal complement activation and poor renal function
| Autor: | Stefan P Berger, Marko J.K. Mallat, Mohamed R. Daha, Machiel A. Siezenga, Reinier N. van der Geest, Ton J. Rabelink |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Urinary system medicine.medical_treatment Renal function Enzyme-Linked Immunosorbent Assay Complement Membrane Attack Complex Kidney Function Tests urologic and male genital diseases Excretion Internal medicine medicine Humans Complement Activation Transplantation Kidney Proteinuria Properdin business.industry Middle Aged medicine.disease Prognosis female genital diseases and pregnancy complications medicine.anatomical_structure Endocrinology Nephrology complement activation properdin proteinuria renal failure tubular epithelial-cells experimental nephrotic syndrome membrane attack complex alternative pathway tubulointerstitial injury progressive nephropathies interstitial disease positive regulator proximal tubules brush-border Kidney Diseases Hemodialysis medicine.symptom business Biomarkers Kidney disease |
| Zdroj: | Nephrology Dialysis Transplantation, 25(4), 1157-1161 |
| Popis: | Background. Proteinuria predicts progressive renal failure. Next to being a progression marker, non-selective proteinuria itself is thought to be toxic to the tubulointerstitium. In proteinuric states, activation of filtered or locally produced complement is toxic for renal tubular cells and likely contributes to the progression of renal failure. Recent experimental evidence suggests an important role for properdin in promoting intrarenal complement activation. We measured properdin in proteinuric urine and assessed its relation with urinary SC5b-9 levels, the soluble form of the effector phase of complement activation. Methods. Seventy patients with renal disease of different origin but all with a protein excretion of at least 1 g/day were studied. Urinary properdin and SC5b-9 levels were measured using an ELISA technique. Results. Properdin was detectable in the urine of 37 patients (53%). These subjects had higher urinary SC5b-9 levels {median 0.50 U/ml [interquartile range (IQR) 0.13-1.81] versus 0.049 U/ml (IQR 0.024-0.089), P < 0.001}. When adjusted for proteinuria and renal function, properdin excretion was strongly associated with increased urinary SC5b-9 levels (odds ratio 16.2, 95% confidence interval 3.6-74.4). Properdin excretion was associated with worse renal function. Conclusion. Our results suggest that urinary properdin excretion enhances intrarenal complement activation and thus may contribute to the progression of renal damage in proteinuric states. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|