Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity

Autor:	Connor A. Tsuchida, Shouyue Zhang, Mohammad Saffari Doost, Yuqian Zhao, Jia Wang, Elizabeth O’Brien, Huan Fang, Cheng-Ping Li, Danyuan Li, Zhuo-Yan Hai, Jonathan Chuck, Julian Brötzmann, Araz Vartoumian, David Burstein, Xiao-Wei Chen, Eva Nogales, Jennifer A. Doudna, Jun-Jie Gogo Liu
Rok vydání:	2022
Předmět:	1.1 Normal biological development and functioning RNA-guided DNA nuclease Medical and Health Sciences Article nucleic acid manipulation Underpinning research Genetics Humans Animals genome editing Clustered Regularly Interspaced Short Palindromic Repeats Kinetoplastida Molecular Biology Mammals Gene Editing DNA cleavage Human Genome Cell Biology Biological Sciences Endonucleases Cas12e structural engineering Infectious Diseases Emerging Infectious Diseases CRISPR RNA cryo-EM Gold sgRNA Generic health relevance CRISPR-Cas Systems CasX Guide Biotechnology Developmental Biology
Zdroj:	Molecular cell, vol 82, iss 6 Mol Cell
ISSN:	1097-2765
Popis:	A compact protein with a size of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c74e0d8fd86f98920edf6dcc0a0e24 https://doi.org/10.1016/j.molcel.2022.02.002 Zobrazit plný text záznamu