Time-course effects of aerobic exercise training on cardiovascular and renal parameters in 2K1C renovascular hypertensive rats

Autor: Andréia Carvalho Alzamora, R.C.A. Maia, Robson A.S. Santos, M.E. Silva, Luiz Eduardo Sousa, Wanderson Geraldo de Lima, Maria José Campagnole-Santos
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
Medicine (General)
Time Factors
Physiology
2K1C renovascular hypertension
Heart and kidney adaptations
Kidney
Surgically-Created Structures
Biochemistry
Renal Artery
Heart Rate
Medicine
General Pharmacology
Toxicology and Pharmaceutics

Biology (General)
lcsh:QH301-705.5
lcsh:R5-920
General Neuroscience
General Medicine
Catalase
medicine.anatomical_structure
Hypertension
Renovascular

Cardiology
medicine.symptom
lcsh:Medicine (General)
Bradycardia
medicine.medical_specialty
Mean arterial pressure
QH301-705.5
Immunology
Biophysics
Ocean Engineering
Baroreflex bradycardia
Thiobarbituric Acid Reactive Substances
R5-920
Internal medicine
Physical Conditioning
Animal

Heart rate
TBARS
Aerobic exercise
Animals
Arterial Pressure
Swimming
business.industry
Myocardium
Biomedical Sciences
Cell Biology
Baroreflex
Rats
Inbred F344

Endocrinology
Blood pressure
lcsh:Biology (General)
Oxidative stress
Reflex bradycardia
Sedentary Behavior
business
Zdroj: Brazilian Journal of Medical and Biological Research, Volume: 48, Issue: 11, Pages: 1010-1022, Published: 11 AUG 2015
Brazilian Journal of Medical and Biological Research v.48 n.11 2015
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Vol 48, Iss 11, Pp 1010-1022 (2015)
Brazilian Journal of Medical and Biological Research, Iss 0, Pp 00-00 (2015)
Popis: Exercise training (Ex) has been recommended for its beneficial effects in hypertensive states. The present study evaluated the time-course effects of Ex without workload on mean arterial pressure (MAP), reflex bradycardia, cardiac and renal histology, and oxidative stress in two-kidney, one-clip (2K1C) hypertensive rats. Male Fischer rats (10 weeks old; 150–180 g) underwent surgery (2K1C or SHAM) and were subsequently divided into a sedentary (SED) group and Ex group (swimming 1 h/day, 5 days/week for 2, 4, 6, 8, or 10 weeks). Until week 4, Ex decreased MAP, increased reflex bradycardia, prevented concentric hypertrophy, reduced collagen deposition in the myocardium and kidneys, decreased the level of thiobarbituric acid-reactive substances (TBARS) in the left ventricle, and increased the catalase (CAT) activity in the left ventricle and both kidneys. From week 6 to week 10, however, MAP and reflex bradycardia in 2K1C Ex rats became similar to those in 2K1C SED rats. Ex effectively reduced heart rate and prevented collagen deposition in the heart and both kidneys up to week 10, and restored the level of TBARS in the left ventricle and clipped kidney and the CAT activity in both kidneys until week 8. Ex without workload for 10 weeks in 2K1C rats provided distinct beneficial effects. The early effects of Ex on cardiovascular function included reversing MAP and reflex bradycardia. The later effects of Ex included preventing structural alterations in the heart and kidney by decreasing oxidative stress and reducing injuries in these organs during hypertension.
Databáze: OpenAIRE