Estrogen and progesterone receptors in endometriosis
| Autor: | William Kondo, Monica Tessmann Zomer, Luiz Ricardo Adriano Ferreira, Edward Araujo Júnior, Teresa Cristina Santos Cavalcanti, Jaime Kulak Júnior |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Infertility
medicine.medical_specialty medicine.drug_class business.industry Hormone Replacement Therapy Endometriosis Obstetrics and Gynecology Estrogen receptor medicine.disease Endocrinology Cross-Sectional Studies Receptors Estrogen Estrogen Hormone receptor Internal medicine medicine Immunohistochemistry Humans Female business Receptor Receptors Progesterone Hormone |
| Zdroj: | Minerva obstetrics and gynecology. 74(4) |
| ISSN: | 2724-6450 |
| Popis: | BACKGROUND This study aims to identify the presence of estrogen and progesterone hormone receptors in endometriosis implants and to determine whether hormone treatment influences the receptors in these implants. METHODS Cross-sectional study with historical data collection. The analysis was conducted on 156 endometriosis implants from 67 patients undergoing endometriosis laparoscopy. The patients were divided into two groups: one group underwent hormone treatment (n = 20) and another group did not receive hormone treatment (n = 47) prior to surgery. Women of reproductive age with clinical pain and/or infertility who were diagnosed with endometriosis and underwent surgery were included. The specimens were analyzed after the estrogen and progesterone hormone receptors underwent immunohistochemistry. RESULTS All analyzed topographies presented estrogen and progesterone hormone receptors. Progesterone hormone receptor expression was considerably superior than estrogen receptor expression (p < 0.001). CONCLUSIONS Hormone receptors are present in endometriosis implants on the ovarian fossae, uterosacral ligaments, sac fundus, and ovaries. Progesterone receptors predominate in implants, regardless of hormonal treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|