Investigation of Topical Ciprofloxacin Ototoxicity in Guinea Pigs
| Autor: | Kerim Ceryan, Bülent Şerbetçioğlu, Ahmet Omer Ikiz, Semih Sütay, Enis Alpin Güneri |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.drug_class Administration Topical Guinea Pigs Antibiotics Silicones Deafness Sodium Chloride Placebos Drug Delivery Systems Anti-Infective Agents Ototoxicity Ciprofloxacin Evoked Potentials Auditory Brain Stem otorhinolaryngologic diseases medicine Animals Antibacterial agent business.industry Topical drug application Auditory Threshold General Medicine medicine.disease Anti-Bacterial Agents Cochlea Auditory brainstem response Otorhinolaryngology Anesthesia Toxicity Female Gentamicin Gentamicins Intubation business Follow-Up Studies medicine.drug |
| Zdroj: | Acta Oto-Laryngologica. 118:808-812 |
| ISSN: | 1651-2251 0001-6489 |
| DOI: | 10.1080/00016489850182486 |
| Popis: | Antibiotic eardrops mostly contain potentially ototoxic aminoglycosides. Ciprofloxacin is an alternative, and there is limited experience in its topical use. To investigate the topical ototoxicity of ciprofloxacin, 11 guinea pigs have been operated on. Transbullae silicone drug delivery tubes were placed to both ears of the animals. After the operation the guinea pigs were divided into two groups. The first group of animals received 0.2 mi of 4% gentamicin in one ear and 0.2 mi of 0.9% sodium chloride solution in the other. The second group received 0.2 mi of 0.2% ciprofloxacin in the test ear and 0.2 mi of 0.9% sodium chloride solution in the control ear. All drugs acre given once a day on 7 consecutive days. Auditory brainstem response thresholds were recorded using click, 4 and 8 kHz logon stimuli before and after the operation, and after topical drug application. Results were statistically compared using Wilcoxon matched pairs signed-ranks test. Comparison of the thresholds before and after the operation, physiological saline application, as well as ciprofloxacin application yielded no statistically significant differences, whereas application of gentamicin resulted in total hearing loss. The results indicate that topical use of 0.2% ciprofloxacin is not ototoxic in guinea pigs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|