Effect of acute and chronic ethanol treatment on rat brain phospholipid turnover
| Autor: | Howard J. Friedman, Nancy M. Lee, Horace H. Loh |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Glycerol
Male medicine.medical_specialty Phospholipid Physical dependence Biochemistry Phosphates chemistry.chemical_compound Internal medicine Phosphatidylcholine medicine Animals Humans Phosphatidylinositol Phospholipids Pharmacology Phosphatidylethanolamine Membranes Ethanol Brain Drug Tolerance Phosphatidylserine Rats Substance Withdrawal Syndrome Alcoholism Endocrinology chemistry Microsome medicine.symptom |
| Zdroj: | Biochemical Pharmacology. 29:2815-2818 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/0006-2952(80)90016-7 |
| Popis: | Phospholipid turnover was studied in the rat brain after treatment in vitro with (1) an acute dose of ethanol, (2) after the development of tolerance to ethanol, (3) of physical dependence on ethanol, and (4) of withdrawal from dependence. It was found that the turnover of phosphatidylcholine, of phosphatidylinosotol/phosphatidylserine and of phosphatidylethanolamine was increased in tolerant animals and that tolerance developed to these increases in dependent animals. A drastic decrease in 32 P-labeled phosphatidylinositol/phosphatidylserine of microsomal fractions was observed in animals withdrawing from dependence. |
| Databáze: | OpenAIRE |
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