Effect of cocaine dependence on brain connections: clinical implications
| Autor: | Liangsuo Ma, Sade E. Johns, Ponnada A. Narayana, F. Gerard Moeller, Joel L. Steinberg |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Resting state fMRI
medicine.diagnostic_test General Neuroscience Treatment outcome Brain Cognition Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Article Cocaine dependence Cocaine-Related Disorders Cocaine Cocaine users medicine Humans Pharmacology (medical) Neurology (clinical) Animal studies Psychology Neuroscience Default mode network |
| Zdroj: | Expert Review of Neurotherapeutics. 15:1307-1319 |
| ISSN: | 1744-8360 1473-7175 |
| DOI: | 10.1586/14737175.2015.1103183 |
| Popis: | Cocaine dependence (CD) is associated with several cognitive deficits. Accumulating evidence, based on human and animal studies, has led to models for interpreting the neural basis of cognitive functions as interactions between functionally related brain regions. In this review, we focus on the magnetic resonance imaging (MRI) studies using brain connectivity techniques as related to CD. The majority of these brain connectivity studies indicated that cocaine use is associated with altered brain connectivity between different structures, including cortical-striatal regions and default mode network. In cocaine users, some of the altered brain connectivity measures are associated with behavioral performance, history of drug use, and treatment outcome. The implications of these brain connectivity findings to the treatment of CD and the pros and cons of the major brain connectivity techniques are discussed. Finally potential future directions in cocaine use disorder research using brain connectivity techniques are briefly described. |
| Databáze: | OpenAIRE |
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