Pre- and post-treatment values of HDL cholesterol and total: HDL cholesterol ratio in hyperlipoproteinaemic subjects
| Autor: | John K. Sale, James H. Johnstone |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
030213 general clinical medicine medicine.medical_specialty Hyperlipoproteinemias Clinical Biochemistry 030209 endocrinology & metabolism Hyperlipoproteinemia Type IV Hyperlipoproteinemia Type II 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Sex Factors Internal medicine Total cholesterol Medicine Humans Clofibrate Pre and post Triglycerides Triglyceride business.industry Cholesterol Cholesterol HDL nutritional and metabolic diseases General Medicine Endocrinology chemistry HDL/cholesterol ratio lipids (amino acids peptides and proteins) Female business Lipoproteins HDL medicine.drug Lipoprotein |
| Zdroj: | Annals of clinical biochemistry. 18 |
| ISSN: | 0004-5632 |
| Popis: | High-density lipoprotein (HDL) cholesterol, total cholesterol, and triglyceride concentrations were measured in fasting blood samples from 74 controls and 185 patients with untreated primary hyperlipoproteinaemia. The mean HDL cholesterol levels and the total cholesterol: HDL cholesterol ratios were significantly different between male and female subjects. Only patients with Fredrickson type IV hyperlipoproteinaemia had HDL cholesterol concentrations significantly lower than the controls, but all subjects with hyperlipoproteinaemia had total: HDL cholesterol ratios significantly higher than control values. Subsequent investigations were performed on 31 patients during treatment of the hyperlipoproteinaemia by diet alone or in combination with clofibrate. Responses were variable, but generally improvements in the concentrations of triglyceride and total cholesterol were accompanied by an unchanged or decreased total: HDL cholesterol ratio, although there was not necessarily an increase in the HDL cholesterol itself. |
| Databáze: | OpenAIRE |
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