Propertiesof intact photoreceptor cells lacking synapses
| Autor: | Timothy H. Goldsmith, Daniel M. Eichenbaum |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
genetic structures
Light Sensory Receptor Cells Central nervous system Receptor potential Neural Conduction Stimulation Tetrodotoxin Biology Eye Feedback chemistry.chemical_compound Houseflies medicine Animals Transplantation Homologous Axon fungi Optic Lobe Nonmammalian Depolarization General Medicine Anatomy Carbon Dioxide Cell biology Imaginal disc medicine.anatomical_structure chemistry Synapses Animal Science and Zoology Soma sense organs |
| Zdroj: | The Journal of experimental zoology. 169(1) |
| ISSN: | 0022-104X |
| Popis: | Surgically undamaged photoreceptor cells that have no connections with the central nervous system were obtained by transplanting the eye imaginal disc of third instar housefly larvae (Musca domestica) into the abdomens of host larvae and waiting for development of the host flies. Following differentiation, the photoreceptor cells of the transplants have normal cell bodies and rhabdomeres. Their axons, on the other hand, do not make synapses with higher order cells. The retinular cells, thus isolated from the optic lobe, give electrical responses to illumination that are indistinguishable from the membrane responses of normal receptor cells, and at moderate intensities of stimulation consist of an initial transient and a plateau. This graded depolarization of the soma (receptor potential) spreads electrotonically into the axon without initiating spikes. Neither CO2 nor tetrodotoxin has an effect on the receptor potential of isolated photoreceptors. The transplants dark adapt at the same rate as normal retinulae, dark adaptation being slower following longer periods of light adaptation. Clearly in flies the development of the synapses of the lamina ganglionaris is not necessary for normal physiological development of the receptors, and the responses of the photoreceptors of normal eyes can be generated without significant feedback control from the optic lobe. |
| Databáze: | OpenAIRE |
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