Anthropometry and the Risk of Lung Cancer in EPIC
| Autor: | Dewi, Nikmah Utami, Boshuizen, Hendriek C, Johansson, Mattias, Vineis, Paolo, Kampman, Ellen, Steffen, Annika, Tjønneland, Anne, Halkjær, Jytte, Overvad, Kim, Severi, Gianluca, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Li, Kuanrong, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Klinaki, Eleni, Tumino, Rosario, Palli, Domenico, Mattiello, Amalia, Tagliabue, Giovanna, Peeters, Petra H, Vermeulen, Roel, Weiderpass, Elisabete, Torhild Gram, Inger, Huerta, José María, Agudo, Antonio, Sánchez, María-José, Ardanaz, Eva, Dorronsoro, Miren, Quirós, José Ramón, Sonestedt, Emily, Johansson, Mikael, Grankvist, Kjell, Key, Tim, Khaw, Kay-Tee, Wareham, Nick, Cross, Amanda J, Norat, Teresa, Riboli, Elio, Fanidi, Anouar, Muller, David, Bueno-de-Mesquita, H Bas, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, dIRAS RA-2 |
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| Přispěvatelé: | LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, dIRAS RA-2, Imperial College Trust |
| Rok vydání: | 2016 |
| Předmět: |
Male
obesity Lung Neoplasms Nutrition and Disease Epidemiology Comorbidity waist to hip ratio ORIGINAL CONTRIBUTIONS Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] 0302 clinical medicine Waist–hip ratio Voeding en Ziekte Multicenter Studies as Topic Medicine Prospective Studies 030212 general & internal medicine POPULATION Public Environmental & Occupational Health Human Nutrition & Health Waist-to-height ratio Anthropometry Hazard ratio Humane Voeding & Gezondheid Confounding Factors Epidemiologic 11 Medical And Health Sciences Middle Aged waist circumference Europe LEANNESS 030220 oncology & carcinogenesis Female Life Sciences & Biomedicine Adult medicine.medical_specialty Waist body mass index waist-to-height ratio Risk Assessment smoking 03 medical and health sciences Journal Article Humans COHORT Lung cancer waist-to-heigh ratio METAANALYSIS 01 Mathematical Sciences Aged Proportional Hazards Models VLAG MODEL ANALYSIS Science & Technology Waist-Hip Ratio business.industry Proportional hazards model CURRENT SMOKERS Cancer FAT DISTRIBUTION medicine.disease Diet Surgery BODY-MASS INDEX lung cancer business Body mass index Demography |
| Zdroj: | American Journal of Epidemiology, 184, 2, pp. 129-139 American Journal of Epidemiology, 184(2), 129. Oxford University Press American Journal of Epidemiology, 184, 129-139 Dewi, N U, Boshuizen, H C, Johansson, M, Vineis, P, Kampman, E, Steffen, A, Tjønneland, A, Halkjær, J, Overvad, K, Severi, G, Fagherazzi, G, Boutron-Ruault, M-C, Kaaks, R, Li, K, Boeing, H, Trichopoulou, A, Bamia, C, Klinaki, E, Tumino, R, Palli, D, Mattiello, A, Tagliabue, G, Peeters, P H, Vermeulen, R, Weiderpass, E, Torhild Gram, I, Huerta, J M, Agudo, A, Sánchez, M-J, Ardanaz, E, Dorronsoro, M, Quirós, J R, Sonestedt, E, Johansson, M, Grankvist, K, Key, T, Khaw, K-T, Wareham, N, Cross, A J, Norat, T, Riboli, E, Fanidi, A, Muller, D & Bueno-de-Mesquita, H B 2016, ' Anthropometry and the Risk of Lung Cancer in EPIC ', American Journal of Epidemiology, vol. 184, no. 2, pp. 129-39 . https://doi.org/10.1093/aje/kwv298 American Journal of Epidemiology 184 (2016) 2 American Journal of Epidemiology, 184(2), 129-139 |
| ISSN: | 0002-9262 |
| DOI: | 10.1093/aje/kwv298 |
| Popis: | The associations of body mass index (BMI) and other anthropometric measurements with lung cancer were examined in 348,108 participants in the European Investigation Into Cancer and Nutrition (EPIC) between 1992 and 2010. The study population included 2,400 case patients with incident lung cancer, and the average length of follow-up was 11 years. Hazard ratios were calculated using Cox proportional hazard models in which we modeled smoking variables with cubic splines. Overall, there was a significant inverse association between BMI (weight (kg)/height (m)(2)) and the risk of lung cancer after adjustment for smoking and other confounders (for BMI of 30.0-34.9 versus 18.5-25.0, hazard ratio = 0.72, 95% confidence interval: 0.62, 0.84). The strength of the association declined with increasing follow-up time. Conversely, after adjustment for BMI, waist circumference and waist-to-height ratio were significantly positively associated with lung cancer risk (for the highest category of waist circumference vs. the lowest, hazard ratio = 1.25, 95% confidence interval: 1.05, 1.50). Given the decline of the inverse association between BMI and lung cancer over time, the association is likely at least partly due to weight loss resulting from preclinical lung cancer that was present at baseline. Residual confounding by smoking could also have influenced our findings. |
| Databáze: | OpenAIRE |
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