Efficacy and toxicity of pemetrexed as a third-line treatment for non-small cell lung cancer
| Autor: | Ho Il Yoon, Jee Hyun Kim, Keun-Wook Lee, Jong-Mu Sun, Jong Seok Lee, Choon-Taek Lee, Yu Jung Kim, Jae Ho Lee |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Antimetabolites Antineoplastic Guanine Lung Neoplasms Maximum Tolerated Dose Salvage therapy Pemetrexed Systemic therapy Medical Records Glutamates Internal medicine Carcinoma Non-Small-Cell Lung medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Lung cancer Survival rate Aged Retrospective Studies Aged 80 and over Salvage Therapy Performance status business.industry Retrospective cohort study General Medicine Thymidylate Synthase Middle Aged medicine.disease Prognosis Survival Rate Treatment Outcome Carcinoma Squamous Cell Female business medicine.drug |
| Zdroj: | Japanese journal of clinical oncology. 39(1) |
| ISSN: | 1465-3621 |
| Popis: | Objective: Pemetrexed has been approved for second-line treatment in non-small cell lung cancer (NSCLC). However, the role of third-line pemetrexed therapy in NSCLC has not yet been generally accepted. We attempted to validate third-line pemetrexed therapy and evaluate predictive factors for pemetrexed therapy for NSCLC. Methods: Medical records of NSCLC patients who received pemetrexed therapy that progressed after systemic therapy were reviewed retrospectively. We stratified patients according to clinicopathologic characteristics to find predictive factors for pemetrexed therapy. Results: A total of 100 patients were eligible for analysis, and overall progression-free survival (PFS) was 3.03 months. The objective response rate was 12%, and the toxicity profile was favorable. Pemetrexed was used as a second-line treatment in 30% of patients, and as third- or further-line treatment in 70%. Comparing the efficacy of pemetrexed in these two settings (second-line versus third- or further-line), there was no significant difference in terms of PFS (3.07 versus 2.83 months, P ¼ 0.86). When we evaluated predictive factors by multivariate analysis, performance status significantly influenced PFS. Conclusions: Pemetrexed is a suitable third-line treatment option with good efficacy and tolerable toxicity profile for NSCLC. |
| Databáze: | OpenAIRE |
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