Circadian rhythm of tryptophan, serotonin, melatonin, and pituitary hormones in schizophrenia
| Autor: | Maria Luise Rao, Angelos Halaris, Peter Bräunig, Gisela Gross, Gerd Huber, Matthew Marler, Bernd Strebel |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Hypothalamo-Hypophyseal System Serotonin endocrine system medicine.medical_specialty Psychosis Adolescent Thyrotropin Melatonin Thyroid-stimulating hormone Reference Values Internal medicine Schizophrenic Psychology medicine Humans Circadian rhythm Biological Psychiatry Aged Chronobiology Tryptophan Neural Inhibition Middle Aged medicine.disease Prolactin Circadian Rhythm Pituitary Hormones Endocrinology Growth Hormone Schizophrenia Female Psychology Antipsychotic Agents medicine.drug |
| Zdroj: | Biological Psychiatry. 35:151-163 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/0006-3223(94)91147-9 |
| Popis: | Circadian rhythm abnormalities have been described mostly with respect to manic-depressive illness; little information is available concerning circadian rhythms and schizophrenia or their influence on neuroleptic drugs. We showed previously that the MESOR of dopamine is higher in schizophrenic patients than in healthy subjects and that women who are drug-free schizophrenic have lower prolactin MESORs and lower amplitudes than healthy women. We now report the data of a cosinor analysis of tryptophan, serotonin, melatonin, and pituitary hormones in the blood of 34 healthy subjects, 90 drug-free schizophrenics, and 25 neuroleptic-treated schizophrenic patients. This data indicated a significant phase advance of serum tryptophan, prolactin, and melatonin concentrations, a trend toward a phase advance in serotonin. Thyroid stimulating hormone (TSH), and growth hormone concentrations, and decreases in the TSH MESORs among patients compared to healthy subjects. These results suggest that circadian changes, such as phase advances and alterations in MESOR, are not only present in depression but also in schizophrenia. Although neuroleptic treatment raised the prolactin MESOR and amplitude, it did not elicit any change in circadian rhythmicity among the other parameters. |
| Databáze: | OpenAIRE |
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