Programmed cell death and the control of cell survival
| Autor: | Yasuki Ishizaki, H. S. R. Coles, Ben A. Barres, Michael D. Jacobson, Martin Raff, Julia F. Burne |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Programmed cell death
Cell Survival Growth factor medicine.medical_treatment Regulator Apoptosis Biology Kidney General Biochemistry Genetics and Molecular Biology Cell biology Cytosol Oligodendroglia Cartilage Organelle Lens Crystalline otorhinolaryngologic diseases Extracellular medicine Animals General Agricultural and Biological Sciences Mitosis |
| Zdroj: | Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 345(1313) |
| ISSN: | 0962-8436 |
| Popis: | We draw the following tentative conclusions from our studies on programmed cell death (PCD): (i) the amount of normal cell death in mammalian development is still underestimated; (ii) most mammalian cells constitutively express the proteins required to undergo PCD ; (iii) the death programme operates by default when a mammalian cell is deprived of signals from other cells; (iv) many normal cell deaths may occur because cells fail to obtain the extracellular signals they need to suppress the death programme; and (v) neither the nucleus nor mitochondrial respiration is required for PCD (or Bcl-2 protection from PCD), raising the possibility that the death programme, like mitosis, is orchestrated by a cytosolic regulator that acts on multiple organelles in parallel. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|