Effects of two Bisphenol A replacement compounds, 1,7-bis (4-hydroxyphenylthio)-3,5-dioxaheptane and Bisphenol AF, on development and mRNA expression in chicken embryos
Autor: | Jason M. O'Brien, Kim L. Williams, Doug Crump, Helina Gyasi, Tasnia Sharin |
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Rok vydání: | 2021 |
Předmět: |
Bisphenol A
Estrone medicine.drug_class Health Toxicology and Mutagenesis Chick Embryo BPAF Environmental pollution Bisphenol AF Andrology DD-70 chemistry.chemical_compound Phenols Gene expression medicine Animals GE1-350 RNA Messenger Benzhydryl Compounds Endocrine disruptors Estrogenic compounds Public Health Environmental and Occupational Health Estrogens Embryo General Medicine Metabolism Pollution Embryonic stem cell Environmental sciences TD172-193.5 Liver chemistry Estrogen Chickens Drug metabolism Avian toxicity |
Zdroj: | Ecotoxicology and Environmental Safety, Vol 215, Iss, Pp 112140-(2021) |
ISSN: | 0147-6513 |
DOI: | 10.1016/j.ecoenv.2021.112140 |
Popis: | Concerns about the estrogenic properties of Bisphenol A (BPA) have led to increased efforts to find BPA replacements. 1,7-bis(4-Hydroxyphenylthio)-3,5-dioxaheptane (DD-70) and 4,4′-(hexafluoroisopropylidene) diphenol (bisphenol AF, BPAF) are two potential chemical substitutes for BPA; however, toxicity data for these chemicals in avian species are limited. To determine effects on avian embryonic viability, development, and hepatic mRNA expression at two distinct developmental periods (mid-incubation [day 11] and term [day 20]), two egg injection studies were performed. Test chemicals were injected into the air cell of unincubated, fertilized chicken eggs at concentrations ranging from 0–88.2 µg/g for DD-70 and 0–114 µg/g egg for BPAF. Embryonic concentrations of DD-70 and BPAF decreased at mid-incubation and term compared to injected concentrations suggesting embryonic metabolism. Exposure to DD-70 (40.9 and 88.2 µg/g) and BPAF (114 µg/g) significantly decreased embryonic viability at mid-incubation. Exposure to DD-70 (88.2 µg/g) decreased embryo mass and increased gallbladder mass, while 114 µg/g BPAF resulted in increased gallbladder mass in term embryos. Expression of hepatic genes related to xenobiotic metabolism, lipid homeostasis, and response to estrogen were altered at both developmental stages. Given the importance of identifying suitable BPA replacements, the present study provides novel, whole animal avian toxicological data for two replacement compounds, DD-70 and BPAF. Data availability Data, associated metadata, and calculation tools are available from the corresponding author (doug.crump@canada.ca). |
Databáze: | OpenAIRE |
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