Evaluation of Cocoa Butter as Potential Lubricant for Coprocessing in Pharmaceutical Tablets

Autor:	Adebolu Adewole Adeagbo, Gbenga Alebiowu
Rok vydání:	2008
Předmět:	Materials science Chemical Phenomena Chemistry Pharmaceutical Pharmaceutical Science Mineralogy chemistry.chemical_element Talc Dosage form Excipients chemistry.chemical_compound Stearate Adhesives Tensile Strength Ultimate tensile strength medicine Magnesium stearate Lubricant Composite material Lubricants Cacao Chemistry Physical Magnesium General Medicine Angle of repose chemistry Powders Stearic Acids Tablets medicine.drug
Zdroj:	Pharmaceutical Development and Technology. 13:197-204
ISSN:	1097-9867 1083-7450
DOI:	10.1080/10837450801949400
Popis:	The lubricant activity of cocoa butter coprocessed with magnesium stearate plus talc (CMT) was compared with magnesium stearate plus talc (MT) using flow and compressional characteristics of paracetamol granules and mechanical properties of their tablets as assessment parameters. The flow of the granules quantified as Hausner's ratio, Carr's index, and angle of repose showed that CMT has a higher ability than MT to reduce densification of granules due to vibration. Compressional characteristics analyzed using density measurements and the Heckel and Kawakita plots revealed that CMT did not facilitate the increase in the densification of the granules during the filling and at low pressures, D(b). Also, CMT reduced the plastic deformation of the granules measured by the P(y)-yield pressure at onset of plastic deformation and P(k)-yield pressure of deformation under compression. The mechanical properties determined by the tensile strength, T, and brittle fracture index, BFI, of the tablets produced were affected by CMT. The T and BFI of tablets with CMT were lower than those of MT. The results suggest that though CMT lowered the plasticity of the granules, it improved their flow rate and assisted in producing tablets with fewer tendencies to cap or laminate. This work concluded that cocoa butter, an inexpensive and easily available lipid, is an effective and viable lubricant that can be co-processed with magnesium stearate/talc mixture for an efficient lubrication of granules and may be useful in reducing lamination and capping in formulations that are susceptible to these 2 defects of tablets.
Databáze:	OpenAIRE
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