Triggered Release from Thermoresponsive Polymersomes with Superparamagnetic Membranes
| Autor: | Erik Reimhult, Oliver Bixner, Steffen Kurzhals, Mudassar Mumtaz Virk |
|---|---|
| Přispěvatelé: | School of Materials Science & Engineering |
| Rok vydání: | 2015 |
| Předmět: |
Thermoresponsive Polymer
Materials science Superparamagnetic Iron Oxide Nanoparticle thermoresponsive polymer Nanoparticle Nanotechnology calcein assay 02 engineering and technology superparamagnetic iron oxide nanoparticle magneto-polymersome magneto-thermal release 010402 general chemistry lcsh:Technology 01 natural sciences Article chemistry.chemical_compound General Materials Science lcsh:Microscopy lcsh:QC120-168.85 lcsh:QH201-278.5 lcsh:T Bilayer Vesicle 021001 nanoscience & nanotechnology 0104 chemical sciences Engineering::Materials [DRNTU] Calcein Membrane chemistry Chemical engineering lcsh:TA1-2040 Permeability (electromagnetism) Polymersome lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering lcsh:Engineering (General). Civil engineering (General) 0210 nano-technology lcsh:TK1-9971 human activities Superparamagnetism |
| Zdroj: | Materials Materials; Volume 9; Issue 1; Pages: 29 Materials, Vol 9, Iss 1, p 29 (2016) |
| ISSN: | 1996-1944 |
| Popis: | Magnetic polymersomes were prepared by self-assembly of the amphiphilic block copolymer poly(isoprene-b-N-isopropylacrylamide) with monodisperse hydrophobic superparamagnetic iron oxide nanoparticles (SPION). The specifically designed thermoresponsive block copolymer allowed for efficient incorporation of the hydrophobic nanoparticles in the membrane core and encapsulation of the water soluble dye calcein in the lumen of the vesicles. Magnetic heating of the embedded SPIONs led to increased bilayer permeability through dehydration of the thermoresponsive PNIPAM block. The entrapped calcein could therefore be released in controlled doses solely through exposure to pulses of an alternating magnetic field. This hybrid SPION-polymersome system demonstrates a possible direction for release applications that merges rational polymersome design with addressed external magnetic field-triggered release through embedded nanomaterials. Published version |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|