| Autor: |
Priscilla A. Furth, Weisheng Wang, Keunsoo Kang, Brendan L. Rooney, Grace Keegan, Vinona Muralidaran, Justin Wong, Charles Shearer, Xiaojun Zou, Jodi A. Flaws |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
The American journal of pathology. 193(1) |
| ISSN: |
1525-2191 |
| Popis: |
Age is a risk factor for human estrogen receptor-positive breast cancer, with highest prevalence following menopause. While transcriptome risk profiling is available for human breast cancers, it is not yet developed for prognostication for primary or secondary breast cancer development utilizing at-risk breast tissue. Both estrogen receptor α (ER) and aromatase overexpression have been linked to human breast cancer. Herein, conditional genetically engineered mouse models of estrogen receptor 1 (Esr1) and cytochrome P450 family 19 subfamily A member 1 (CYP19A1) were used to show that induction of Esr1 overexpression just before or with reproductive senescence and maintained through age 30 months resulted in significantly higher prevalence of estrogen receptor-positive adenocarcinomas than CYP19A1 overexpression. All adenocarcinomas tested showed high percentages of ER |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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