Modulation of regulatory T cell-Th17 balance by plasmacytoid dendritic cells
| Autor: | Régis Josien, Michèle Heslan, Laetitia Gautreau, Dominique Chabannes |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Regulatory T cell
T-Lymphocytes Immunology Enzyme-Linked Immunosorbent Assay chemical and pharmacologic phenomena Biology T-Lymphocytes Regulatory Mice Immune system medicine Animals Immunology and Allergy Secretion Interleukin 6 Interleukin-6 Interleukin-17 Interleukin-2 Receptor alpha Subunit FOXP3 Cell Differentiation Forkhead Transcription Factors hemic and immune systems Dendritic Cells Cell Biology Phenotype In vitro Rats Mice Inbred C57BL Transplantation medicine.anatomical_structure Rats Inbred Lew Mice Inbred CBA biology.protein Cytokines |
| Zdroj: | Journal of Leukocyte Biology. 90:521-527 |
| ISSN: | 1938-3673 0741-5400 |
| Popis: | Tregs represent an interesting therapeutic tool to modulate immune responses that could be deleterious in autoimmune diseases and in transplantation. However, phenotype and functions of Tregs do not seem to be stable, and recent data suggest that FoxP3-expressing Tregs can be driven to produce IL-17. In this study, we have analyzed the role of pDCs versus cDCs on Treg responses and underlined that pDCs have an intrinsic, unique capacity to induce IL-17 secretion from T cells. We showed in rats that FoxP3+ Tregs were able to secrete IL-17 only when stimulated by allogeneic, mature pDCs but not cDCs. In addition, in rats and mice, mature pDCs but not cDCs inhibited in vitro Treg-suppressive functions and in the presence of Tregs, supported Th17 differentiation from naive T cells through secretion of high amounts of IL-6. These data suggest an important role for pDCs in modulating or switching Treg function and allowing Th17 differentiation. |
| Databáze: | OpenAIRE |
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