| Autor: |
Na Li, Guilong Wu, Li Tang, Wei Zhou, Sha Yang, Qi Pan, Minghui Wang, Peixian Wu, Hao Xiao, Yuxuan He, Xiaofeng Tan, Qinglai Yang |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
ACS applied materialsinterfaces. 14(41) |
| ISSN: |
1944-8252 |
| Popis: |
Pathogenic bacteria infections bring about a substantial risk to human health. Given the development of antibiotic-resistance bacteria, alternative antibacterial strategies with great inactivation efficiency and bacteria-binding ability are extremely attractive. In this work, a metabolic labeling photosensitizer, prepared by the coupling of commercial IR820 and d-propargylglycine (a type of d-amino acid, DAA) via a straightforward one-step incubation (IR820-DAA), could metabolically be incorporated into the bacterial wall via enzymatic reactions, thus enhancing antibacterial efficiency. The laser energy at 808 nm could make IR820-DAA a synergistic photothermal/photodynamic agent for efficient antibacterial therapy and wound healing. Furthermore, IR820-DAA exhibits good water solubility and biological safety for clinical translation and even possesses biofilm degradation activity toward methicillin-resistant |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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