Role of Exercise in Skeletal Muscle Atrophy: A Mechanistic Investigation
| Autor: | Hyun Seok Bang, Jun Hyun Bae, Dae Yun Seo, Yi Sub Kwak |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty exercise business.industry aging Public Health Environmental and Occupational Health lcsh:TX341-641 Physical Therapy Sports Therapy and Rehabilitation sarcopenia lcsh:Biochemistry 03 medical and health sciences skeletal muscle atrophy 030104 developmental biology 0302 clinical medicine Endocrinology Physiology (medical) Internal medicine Medicine lcsh:QD415-436 business lcsh:Nutrition. Foods and food supply 030217 neurology & neurosurgery Skeletal muscle atrophy |
| Zdroj: | 운동과학, Vol 29, Iss 3, Pp 202-207 (2020) |
| ISSN: | 2384-0544 1226-1726 |
| DOI: | 10.15857/ksep.2020.29.3.202 |
| Popis: | PURPOSE: Skeletal muscle atrophy induces overall health problems and many related diseases in older adults. In particular, sarcopenia is related to lowered quality of life, decreased physical activity, high levels of morbidity and mortality owing to chronic diseases, and even falling. Despite the many clinical studies on skeletal muscle atrophy, a little study had been about the exact mechanism of skeletal muscle atrophy at the molecular level. In 2017, A disease code (ICD-10-CM) for skeletal muscle atrophy related to sarcopenia was announced to attempt a clinical approach in the United States. According to these approaches, non-invasive clinical treatment is the most effective method for treating skeletal muscle atrophy. The purpose of this study was to analyze the molecular mechanisms of muscular exercise and related skeletal muscle atrophy factors.METHODS: This systemic review focused on skeletal muscle atrophy and muscular exercise. The keywords were used on “MeSH: muscle atrophy OR skeletal muscle atrophy OR muscle OR atrophy AND physical exercise OR exercise OR exercise training” for English and Korean. This paper searched PubMED, OVIDMEDLINE, and EMBASE for literature consideration.RESULTS: Skeletal muscle atrophy was related to a complex molecular network, and exercise affects IGF-1/Akt/mTOR signaling. The related skeletal muscle atrophy factors were evaluated as MurF1, MAFbx, IGF-1, and NFkB. We proposed new related factors such as ATF 4, Gadd45a, and p21; however, the results related to exercise were not shown in recent studies.CONCLUSIONS: In conclusion, we identified skeletal muscle atrophy factors at the molecular level of muscle physiology, and these new factors may become an interesting field of study in clinical human trial and animal studies. |
| Databáze: | OpenAIRE |
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