Hormonal response to orthostasis in elderly people with systemic systolic hypertension
| Autor: | Norma E. Hill, Harold Smulyan, S Mookherjee, Suman Vardan, Kishan G. Mehrotra |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Systolic hypertension Essential hypertension Plasma renin activity Norepinephrine (medication) Renin-Angiotensin System Orthostatic vital signs Norepinephrine Atrial natriuretic peptide Tilt-Table Test Internal medicine Medicine Humans Cardiac Output Aldosterone Aged business.industry Hemodynamics General Medicine Middle Aged medicine.disease medicine.anatomical_structure Blood pressure Endocrinology Hypertension Vascular resistance Cardiology Vascular Resistance Cardiology and Cardiovascular Medicine business Atrial Natriuretic Factor medicine.drug |
| Zdroj: | Coronary artery disease. 9(9) |
| ISSN: | 0954-6928 |
| Popis: | BACKGROUND Orthostatic hypotension is a common phenomenon in the elderly. Hormonal changes during orthostatic stress have been described in elderly normotensive people and in those with essential hypertension. However, the hormonal response in elderly people who have systolic hypertension during orthostasis has not yet been quantified. METHODS In this study we investigated 14 non-diabetic men, aged 60 to 75 years, with untreated systolic hypertension who were subjected to 45 degrees passive head-up incline on a tilt table for 15 min. Their hormonal profile and hemodynamic changes were analyzed before and after the stress. RESULTS In the supine position, plasma levels of norepinephrine, atrial natriuretic peptide and aldosterone were in the normal range, while the plasma renin activity was low. Immediately upon tilt the systolic blood pressure fell but it reverted to baseline values after 15 min of orthostasis. At that time the cardiac output decreased while the systemic vascular resistance and the plasma norepinephrine concentration rose. The atrial natriuretic peptide appeared to fall, and the renin-aldosterone level did not change. CONCLUSION The physiologic response to orthostatic stress in elderly people with systolic hypertension is comparable to that of elderly normotensive people and those with essential hypertension, i.e. a decrease in cardiac output and an increase in plasma norepinephrine levels. The atrial natriuretic peptide appeared to fall appropriately. The response of the renin-aldosterone system mimicked that in elderly patients with low renin essential isolated hypertension. These observations may have a bearing on the management of elderly people with systolic hypertension who also have orthostatic symptoms; they may not require a different approach from that needed for others of the same age group. |
| Databáze: | OpenAIRE |
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